A method for age dating of uranium mineral particles by double focusing magnetic sector inductively coupled mass spectrometry (FS-ICPMS) and thermal ionization mass spectrometry (TIMS) was presented. Pb/U ratio in uranium mineral particles was measured by FS-ICPMS without any chemical separation procedure. Pb isotope composition in uranium mineral particles was determined by TIMS associated with micro column anion exchange resin method. Due to simplified chemical procedure and minimum use of reagents, the full procedure blank was reduced to 230 pg Pb, leading to the successful age dating of uranium mineral particles with relative standard deviation less than 2%.