0引言有限元方法(Finite Element Method)随着电子计算机的发展而迅速发展起来的一种现代计算方法。它是50年代首先在连续体力学领域、动态特性分析中应用的一种有效的数值分析方法,随后很快广泛的应用于求解热传导、电磁场、流体力学等连续性问题。Sergey等人[1]曾基于有限元的方法做过气泡动力学方面的分析。本文基于有限元方法。
Hyperthermia effects (39-44°C) induced by pulsed high-intensity focused ultrasound (HIFU) have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43°C for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU (1.17 MHz, 5300 W/cm2 , with relatively low-duty ratios (0.2%-4.3%). The results show that: (1) with constant pulse repetition frequency (PRF) (e.g., 1 Hz), the thermal responses inside the vessel will increase with the increasing duty ratio; (2) a temperature elevation to 43°C can be identified at the duty ratio of 4.3%; (3) with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; (4) as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.
