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湖北省自然科学基金(2012FFB02304)

作品数:3 被引量:6H指数:2
相关作者:胡军李贵刚孙坚王志涛李新宇更多>>
相关机构:华中科技大学武汉大学湖北省中医院更多>>
发文基金:湖北省自然科学基金更多>>
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Effect of Methyl-CpG Binding Domain Protein 2(MBD2) on AMD-like Lesions in ApoE-Deficient Mice被引量:3
2014年
Summary: The role of methyl-CpG binding domain protein 2 (MBD2) in an ApoE-deficient mouse model of age-related macular degeneration (AMD) was investigated. Eight-week-old Mbd2/ApoE double deficient (Mbd2^-/- ApoE^-/-) mice (n=12, 24 eyes, experimental group) and MBD2 (wt) ApoE^-/- mice (n=12, 24 eyes, control group) were fed on Western-type diet for 4 months. The mice were sacrificed, and total serum cholesterol levels were analyzed and Bruch's membrane (BM) of the eyes was removed for ultrastructural observation by transmission electron microscopy. Moreover, intercellular adhesion molecule 1 (ICAM-1) immunoreactivities were evaluated by fluorescence microscopy in sections of the eyes in both groups for further understanding the function mechanism of MBD2. There was no significant difference in the total serum cholesterol levels between control group and experimental group (P〉0.05). Transmission electron microscopy revealed that AMD-like lesions, various vacuoles accumulated on BM, notable outer collagenous layer deposits and dilated basal infoldings of retinal pigment epithelium (RPE) were seen in both groups, and the BM in control group was significantly thickened as compared with experimental group (P〈0.05). Fluorescence micrographs exhibited the expression of ICAM-1 in choroid was higher in control group than in experimental group. We are led to conclude that MBD2 gene knockout may lead to accumulation of more deposits on the BM and influence the pathogenesis of AMD via triggering endothelial activation and inflammatory response in choroid, improving microcirculation, and reducing lipid deposition so as to inhibit the development of AMD-like lesions. Our study helps to provide a new therapeutic approach for the clinical treatment of AMD.
潘俊如王琛余其林张述李斌胡军
图形翻转视觉诱发电位检查对白内障术后视力评估的价值被引量:3
2013年
目的:探讨图形翻转视觉诱发电位(pattern reversal visual evoked potential,PRVEP)检查对白内障术后视力评估的价值。方法:回顾性分析2012-10/2013-05在同济医院眼科住院,并在白内障超声乳化术及人工晶状体植入手术前后接受PRVEP检查的的成年白内障患者72例114眼的病例资料,其中76眼为老年性白内障,38眼为并发性白内障。根据晶状体混浊程度及晶状体核硬度将数据分为两组:核硬度Ⅰ,Ⅱ,Ⅲ级为A组,核硬度Ⅳ,Ⅴ级为B组,应用统计学方法进行数据间的相关性分析。结果:A组:(1)术前:视力平均值为0.344,PRVEP检查P100波的潜伏期平均值为107ms,N75-P100波的振幅平均值为4.633μV;术后:视力平均值为0.672,PRVEP检查P100波的潜伏期平均值为104.37ms,N75-P100波的振幅平均值为4.400μV。(2)手术前后视力与P100波的潜伏期呈显著负相关(P<0.01);手术前后视力与N75-P100波的振幅呈显著正相关(术前P<0.01,术后P<0.05)。(3)手术前后视力改善行数与P100波的潜伏期变化值无相关性。B组:(1)术前:视力平均值为0.116,P100波的潜伏期平均值为118.905ms,N75-P100波的振幅值为1.650μV;术后:视力平均值为0.576,P100波的潜伏期平均值为108.429ms,N75-P100波的振幅值5.132μV。(2)术前视力与P100波的潜伏期呈现显著负相关(P<0.05),而术后视力与P100波的潜伏期没有相关性;手术前后视力与N75-P100波的振幅没有相关性。(3)手术前后视力改善行数与P100波的潜伏期变化值没有相关性。结论:由白内障手术前后两组视力与PRVEP的P100波的潜伏期及N75-P100波的振幅的相关性可知,PRVEP受患者术前视力(即屈光间质混浊程度)影响较大,PRVEP检查不能作为白内障术后视力预后的判断指标,白内障手术前的PRVEP检查没有临床意义。
郑一晨白仙芝李贵刚王志涛孙坚李新宇胡军
关键词:图形翻转视觉诱发电位白内障
泪道逆行插管联合鱼腥草注射液冲洗泪道治疗慢性泪囊炎
2014年
目的:观察泪道逆行插管联合鱼腥草注射液冲洗泪道治疗慢性泪囊炎的临床疗效。方法:临床收集的慢性泪囊炎患者176例(205眼),随机分成2组,治疗组(A组)73例(83眼),对照组(B组)103例(122眼)。局麻下行逆行泪道插管术,A组术后加用鱼腥草注射液冲洗泪道;根据患者病情或患者要求置管至少保留半年以上,拔管后,泪道注入妥布霉素地塞米松眼膏3-5次,并定期冲洗泪道;随访6月至3年,平均1.5年。结果:A组治愈率为77.11%,B组治愈率为66.39%,两组治愈率经统计学分析差异有统计学意义(χ2=2.946,P<0.01)。结论:鼻泪管逆植球头硅胶管联合鱼腥草注射液冲洗治疗慢性泪囊炎,操作简便,痛苦小、面部不留疤痕,既经济又无明显毒副作用,成功率较高,值得推广使用。
欧阳丽李杜军罗继红胡军
关键词:慢性泪囊炎泪道插管鱼腥草注射液
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