To explore the dynamic effects of exercise on IRS-2 protein content and tyrosine phosphorylation in DM rats,Sixty SD rats were divided into six groups: normal control group(NC)、diabetes mellitus group(DMC) and exercise group.The exercise groups exercised for different periods of time.The content and tyrosine phosphorylation of IRS-2 protein were measured by Western bolt analysis.Result showed that contents of IRS-2 protein in 60,120,180 min groups were enhanced up to 19.0%,22.4% and 17.2%(P<0.01) respectively,and the tyrosine phosphorylation of IRS-2 protein in 60,120,180 min group enhanced up to 43.1%,80.4% and 53%(P<0.01) respectively,compared with the DMC group.We concluded that that the contents and the tyrosine phosphorylation of IRS-2 protein had obvious time trait after exercise.
