Borondipyrromethenes(BODIPY) are a class of fluorescent dyes whose fluorescence quantum yields are generally high and independent of the solvent.In this paper,we report the synthesis of a new type of BODIPY compound that carries an azido group on the 3-position of the pyrrole core.The azido group quenches the fluorescence of the dye due to its weak electron-donating effect.The fluorescence of the BODIPY dye can be switched on after reacting with alkynes via a Cu(Ⅰ) catalyzed azide-alkyne cycloaddition(CuAAC) reaction.We further demonstrate that this azido-BODIPY compound can be used in the cell imaging applications.
WANG ChaoXIE FangSUTHIWANGCHAROEN NisarapornSUN JianWANG Qian
A concise method was developed to prepare chiral a-monofluorinated-β-amino esters through N-sulfinyl urea catalyzed asymmetric hydrosilylation of a-fluoro-β-enamino esters, which affords high yields, good to high di- astereoselectivities （up to〉99/1）, and moderate to good enantioselectivities （up to 83% ee）.
