Enhanced speech based on the traditional wavelet threshold function had auditory oscillation distortion and the low signal-to-noise ratio (SNR). In order to solve these problems, a new continuous differentiable threshold function for speech enhancement was presented. Firstly, the function adopted narrow threshold areas, preserved the smaller signal speech, and improved the speech quality; secondly, based on the properties of the continuous differentiable and non-fixed deviation, each area function was attained gradually by using the method of mathematical derivation. It ensured that enhanced speech was continuous and smooth; it removed the auditory oscillation distortion; finally, combined with the Bark wavelet packets, it further improved human auditory perception. Experimental results show that the segmental SNR and PESQ (perceptual evaluation of speech quality) of the enhanced speech using this method increase effectively, compared with the existing speech enhancement algorithms based on wavelet threshold.