The omni-directional reflection characteristics of one-dimensional photonic crystals composed of Ta2O5/MgF2 multi-quantum well (MQW) are studied using the transfer matrix method. An omnidirectional reflector consisting of three and four Ta2O5/MgF2 MQWs is investigated. Results show that the photonic band gap of the photonic crystal composed of three and four Ta2O5/MgF2 MQWs, which are within the wavelength ranges of 402-712 and 412-1,023 nm, respectively, could cover the entire visible region. The relationship among the width of the band gap, its location, reflectivity rate, and incident angle of the incident light is analyzed. The optimal structural parameters of the MQW of the omni-directional reflector in the visible region are also calculated. The calculations provide a guide for the design of omni- directional reflection devices in the visible region.