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国家重点基础研究发展计划(Techlogy)

作品数:3 被引量:30H指数:2
发文基金:国家重点基础研究发展计划中国博士后科学基金国家自然科学基金更多>>
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Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats被引量:3
2012年
WANG Huai-qingZOU Jun-jieZHOU Xiang-haiJI Li-nongLIU Zhi-min
关键词:链脲佐菌素褪黑激素
Pretreatment with Tongxinluo protects porcine myocardium from ischaemia/reperfusion injury through a nitric oxide related mechanism被引量:27
2009年
繁体中文药 Tongxinluo 能保护的背景对 ischaemia/reperfusion 损害的心肌层,而是它的行动的机制很好没被记录。我们在 Tongxinluo 的保护的角色检验了氮的氧化物的参与。方法 Miniswine 被使随机化到四组七:假冒,有氮的氧化物 synthase 禁止者 N-nitro-L-arginine 的控制, Tongxinluo 和 Tongxinluo coadministration (L-NNA, 10 mg/kg i.v ) 。在 Tongxinluo 的管理以后的三个小时,动物是 anaesthetised,左前面的下降冠的动脉绑扎并且为 90 在 situ 坚持说分钟在死亡前到 3 小时灌注列在后面。区域不回流并且坏死和风险区域被测面积池病理地决定。在心肌层的嗜中性的累积的度被测量 myeloperoxidase 活动和组织学的分析获得。氮的氧化物 synthase 活动和脉管的 endothelial cadherin 满足的心肌的 endothelial 被比色的方法测量, immunoblotting 分析 respectively.Results Tongxinluo 显著地增加了本地血流动并且限制了梗塞和尺寸不回流。Tongxinluo 也在组织学的节稀释了 myeloperoxidase 活动和嗜中性的累积并且维持了脉管的 endothelial cadherin 和 endothelial 的水平在 reflow 区域的氮的氧化物 synthase 活动什么时候与控制相比组。Tongxinluo 的保护被 coadministration 与 L-NNA 抵抗。结论 Tongxinluo 可以限制心肌的 ischaemia 并且保护心免于灌注损害。Tongxinluo 由改变 endothelial 的活动调整氮的氧化物的合成氮的氧化物 synthase。
CHENG Yu-tongYANG Yue-jinZHANG Hai-taoQIAN Hai-yanZHAO Jing-linMENG Xian-minLUO Fu-liangWU Yi-ling
关键词:猪心肌
Tides and Turbulent Mixing in the North of Taiwan Island
2019年
Microstructure and hydrological profiles were collected along two cross-shelf sections from the deep slope to the shallow water in the north of Taiwan Island in the summer of 2006. While the tidal currents on the shelf were dominated by the barotropic tide with the current ellipse stretched across the shelf, significant internal tides were observed on the slope. The depth-mean turbulent kinetic energy(TKE) dissipation rate on the shelf was 10^(-6)W kg-1, corresponding to a diapycnal diffusivity of 10^(-2)m^2s^(-1). The depth-mean TKE dissipation rate on the slope was 1 × 10^(-7)W kg-1, with diapycnal diffusivity of 3.4 × 10^(-4)m^2s^(-1). The shear instability associated with internal tides largely contributed to the TKE dissipation rate on the slope from the surface to 150 m, while the enhanced turbulence on the shelf was dominated by tidal or residual current dissipations caused by friction in the thick bottom boundary layer(BBL). In the BBL, the Ekman currents associated with the northeastward Taiwan Warm Current were identified, showing a near-bottom velocity spiral, which agreed well with the analytical bottom Ekman solution.
Xiangzhou SONGDexing WUXiaohui XIE
关键词:湍流混合内潮
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