Finite element modeling on a highly conceptualized 2-D model of fluid flow and heat transport is undertaken to simulate the paleo-hydrological system as if the Mount Isa deposits were being formed in the Mount Isa basin, Northern Australia, and to evaluate the potential of buoyancy force in driving basin-scale fluid flow for the formation of sedimentary-exhalative (SEDEX) deposits. Our numerical case studies indicate that buoyancy-driven fluid flow is controlled mainly by the fault penetration depth and its spatial relation with the aquifer. Marine water recharges the basin via one fault and flows through the aquifer where it is heated from below. The heated metalliferous fluid discharges to the basin floor via the other fault. The venting fluid temperatures are computed to be in the range of 115 to 160°C, with fluid velocities of 2.6 to 4.1 m/year over a period of 1 Ma. These conditions are suitable for the formation of a Mount Isa-sized zinc deposit, provided a suitable chemical trap environment is present. Buoyancy force is therefore a viable driving mechanism for basin-scale ore-forming hydrothermal fluid migration, and it is strong enough to lead to the genesis of supergiant SEDEX deposits like the Mount Isa deposit, Northern Australia.