A hybrid grid generation technique and a multigrid/parallel algorithm are presented in this paper for turbulence flow simulations over three-dimensional (3D) complex geometries. The hybrid grid generation technique is based on an agglomeration method of anisotropic tetrahedrons. Firstly, the complex computational domain is covered by pure tetrahedral grids, in which anisotropic tetrahedrons are adopted to discrete the boundary layer and isotropic tetrahedrons in the outer field. Then, the anisotropic tetrahedrons in the boundary layer are agglomerated to generate prismatic grids. The agglomeration method can improve the grid quality in boundary layer and reduce the grid quantity to enhance the numerical accuracy and efficiency. In order to accelerate the convergence history, a multigrid/parallel algorithm is developed also based on anisotropic agglomeration approach. The numerical results demonstrate the excellent accelerating capability of this multigrid method.