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国家自然科学基金(30930103)

作品数:2 被引量:28H指数:2
发文基金:国家自然科学基金国家重点基础研究发展计划更多>>
相关领域:医药卫生生物学更多>>

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Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression,angiogenesis,invasion and metastasis被引量:10
2010年
Growing evidence suggests that myeloid-derived suppressor cells (MDSCs),which have been named "immature myeloid cells" or "myeloid suppressor cells" (MSCs),play a critical role during the progression of cancer in tumor-bearing mice and cancer patients.As their name implies,these cells are derived from bone marrow and have a tremendous potential to suppress immune responses.Recent studies indicated that these cells also have a crucial role in tumor progression.MDSCs can directly incorporate into tumor endothelium.They secret many pro-angiogenic factors as well.In addition,they play an essential role in cancer invasion and metastasis through inducing the production of matrix metalloproteinases (MMPs),chemoattractants and creating a pre-metastatic environment.Increasing evidence supports the idea that cancer stem cells (CSCs) are responsible for tumorigenesis,resistance to therapies,invasion and metastasis.Here,we hypothesize that CSCs may "hijack" MDSCs for use as alternative niche cells,leading to the maintenance of stemness and enhanced chemo-and radio-therapy resistance.The countermeasure that directly targets to MDSCs may be useful for against angiogenesis and preventing cancer from invasion and metastasis.Therefore,the study of MDSCs is important to understand tumor progression and to enhance the therapeutic efficacy against cancer.
Xian-Zong Ye Shi-Cang Yu Xiu-Wu Bian
关键词:ANGIOGENESISINVASIONMETASTASIS
Contribution of cancer stem cells to angiogenesis and invasion
<正>Background Cancer stem cells:a small fraction of glioma cells with potentials of self-renewal,differentiati...
卞修武
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ALOX-5介导诺帝抑制胶质瘤干细胞自我更新、诱导分化和逆转其凋亡抵抗的作用
目的检测诺帝抗胶质瘤干细胞(GSCs)的作用。方法和结果通过条件筛选培养获得的GSCs高表达的ALOX-5;以脂氧化酶抑制剂筛选试剂盒、CCK-8试剂盒、软琼脂克隆形成试验、流式细胞术、免疫荧光等方法发现诺帝通过降低AL...
王斌卞修武平轶芳姜建勇赵林涛余世沧王喆
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Contribution of cancer stem cells to tumor vasculogenic mimicry被引量:18
2011年
Vasculogenic mimicry(VM),a newly-defined pattern of tumor blood supply,provides a special passage without endothelial cells and is conspicuously different from angiogenesis and vasculogenesis.The biological features of the tumor cells that form VM remain unknown.Cancer stem cells(CSCs)are believed to be tumorinitiating cells,capable of self-renewal and multipotent differentiation,which resemble normal stem cells in phenotype and function.Recently CSCs have been shown to contribute to VM formation as well as angiogenesis.These findings challenge the previous understanding of the cellular basis of VM formation.In this review,we present evidence for participation of CSCs in VM formation.We also discuss the potential mechanisms and possible interaction of CSCs with various elements in tumor microenvironment niche.Based on the importance of VM in tumor progression,it constitutes a novel therapeutic target for cancer.
Xiao-hong YaoYi-fang PingXiu-wu Bian
关键词:NICHEMICROENVIRONMENT
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