A facile and efficient method for the stereoselective synthesis of β-amino acid esters via SmI2-promoted imino-Reformatsky reaction is described.Asymmetric addition of tert-butyl bromoacetate to N-tert-butanesulfinyl aldimines afforded β-amino acid esters in moderate to high yields with excellent diastereoselectivities.The synthetic utilities of the tert-butyl β-amino acid esters were expanded by the preparation of β-lactams and 3-aminoindan-1-ones derivatives.
A convenient and efficient method for the preparation of α-substituted β-amino acids has been developed by reacting compound 2 with various boric acid/borate 3 through Suzuki coupling reaction,which gave multiple structure types of substituted Ni（II） complexes 4 in high yields.Hydrogenation and hydrolysis of complexes 4 led to the corresponding α-substituted β-amino acids.
＜正＞Isocoumarins are key core structural subunits that occur in a wide variety of biologically active natural p...
Guannan Liu,~a Yu Zhou,~a Deju Ye,~a Dengyou Zhang,~a Xiao Ding,~a Hualiang Jiang,~a Hong Liu~(a,*) a Drug Discovery and Design Centre,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Science 555 Zuchongzhi Road,Shanghai 201203,China
