Microwave radiation was applied to the detection of metamizole sodium by cyclic voltammetry. The electrochemical characteristics of metamizole sodium were studied by cyclic voltammetry at GC electrode under microwave radiation and a considerable current enhancement was observed for metamizole sodium in aqueous 0.05 mol/L H2SO4. Under the optional conditions, metamizole sodium was determined in the absence and presence of microwave activation. In the absence of microwave activation cyclic voltammogram of metamizole sodium shows good linear relationship in a concentration range of 8.0×10^-5-1.0×10^-3 mol/L in aqueous 0.05 mol/L H2SO4 with a detection limit of 6.75× 10^-6 mol/L（S/N=3） and the equation of linear regression is Ip=12.973c-0.1905（R^2=0.9996, n=6）; in the presence of 80 W microwave activation cyclic voltammogram of metamizole sodiumin shows good linear relationship in a concentration range of 4.0× 10^-5-1.0×10^-3 mol/L in aqueous 0.05 mol/L H2SO4 with a detection limit of 4,41 × 10^-6 mol/L（S/N=3） and the equation of linear regression is Ip=25.107c-0.1193（R^2=0.9973, n=7）. The current in the presence of 80 W microwave activation increases to about 2 orders of magnitude compared with that in the absence of microwave activation. The proposed method in the presence of microwave activation showed high selectivity and sensitivity, and the sampling of the disposal method is simple. The method was verified by the determination of Metamizole Sodium tablet with satisfactory results.
LI Li-junCHENG Long-junCAI ZhuoLAN Su-meiGUO Xiao-feiLI Yan-qing
