A new species of the genus Odorrana is described from a completely dark karst cave of northeastern Guangxi, southern China. The new species, Odorrana lipuensis sp. nov., can be distinguished from its congeners by a combination of the following characters: medium size(SVL: 40.7–47.7 mm in males, 51.1–55.4 mm in females); tips of all but first finger expanded with circummarginal grooves; smooth, grass-green dorsum with irregular brown mottling; pineal body invisible; throat to upper abdomen with gray mottling; dorsal surfaces of limbs with brown bands; dorsolateral fold absent; tiny spinules on lateral body, temporal region, and anterior and posterior edge of tympanum; white nuptial pad present on finger I; males lacking vocal sacs; females having creamy yellow eggs, without black poles. Uncorrected sequence divergences between O. lipuensis sp. nov. and all homologous 16 S rRNA sequences of Odorrana available on Gen Bank is equal to or greater than 4.9%. Currently, the new species is only known from the type locality.