To improve the dynamic characteristics and the coupling capability, a new predictive functional control algorithm is proposed for strong coupling multivariable systems with time delay, which combines predictive functional control and decoupliug control. First, a decoupling control algorithm is proposed, in which first-order models with time delay are established by analyzing the amplitude-frequency and phase-frequency characteristics of the decoupled subject. Then, a controller is designed for the single-variable subjects after decoupling based on the principles of predictive functional control. The simulation results show that this proposed algorithm has less online computation time and faster tracking. It can provide a more effective control for complex multivariable systems.