Due to climate changes, most of the alpine glaciers have retreated dramatically during the past decades. Thus it is significant to predict the alpine glacier variability in the future for a better understanding of the impact of climate changes on water resource. In this paper, we perform the numerical simulation on Urumqi Glacier No.1 in the eastern Tianshan, central Asia (hereafter Glacier No.1 for short) by considering both the mass balance and ice flow. Given the shape of the Glacier No.1, the velocity of the glacier is obtained by solving a two-dimensional nonlinear Stokes equation and simulated result is in agreement with the observation. In order to predict the variability of Glacier No.1 in the next decades, a climatic scenario is constructed with a temperature rise rate as 0.17°C/10 a and precipitation as constant during the period of 2005-2070. The simulation shows that, the glacier terminus will retreat slowly and the glacier will thin dramatically before 2040, while after year 2040, the glacier terminus retreat will accelerate. This study confirms the increasing retreat rate of alpine glaciers under global warming.