The early Mesozoic granodiorites (ca.165 Ma) in the northeastern Hunan Province (NEH) have SiO2=65.4-69.65%, K2O/Na2O=0.95-1.38 and K2O+Na2O>6%, A/CNK=0.96-1.13 and belong to metaluminous high-K calc-alkaline series. They are characterized by LREE and LILEs enrichment, and HFSE depletion with slightly negative Eu anomalies (Eu/Eu*=0.62-0.90). The initial 87Sr/86Sr ratios are in range from 0.711458 to 0.717461, and εNd values vary from -9.4 to -12.3, distinct from those of the contemporaneous granodiorites mantle-derived from the Southeastern Hunan Province (SEH) (87Sr/86Sr(i)=0.707962~0.710396, εNd(t)=-6.98~-2.30). By contrast, such signatures are roughly similar to those of the neighboring other Mesozoic granitic plutons (Eu/Eu*=0.30-0.70; 87Sr/86Sr >0.710; εNd = -12 to -16) in South China Block (SCB), which have been interpreted as the remelting products of Precambrian basement. The Proterozoic lower-middle crust is an important contributor to the petrogenesis of these early Mesozoic granodiorites in the NEH. An intracontinental extension setting is present in the northeastern Hunan Province at that time due to the demand of enough thermal transfer.