A novel method was proposed for the in situ synthesis of magnetite-containing mesoporous silica SBA- 16 via a sol-gel process coupled with precipitation and oxidation. The effect of the added amounts of reactants on the mesostructural and magnetic properties of the magnetic mesoporous silica was inves- tigated, It was determined that the synthesized magnetic mesoporous silica with a total pore volume of 0.64-0.96 cm3/g and an average pore diameter of 4.0-14,9 nm had a relatively high saturation mag- netization value （1.11-5.77 emu/g） and a large surface area （258-747 m2/g）, Lysozyme was chosen as a model protein to test the performance of the magnetic mesoporous silica as a protein adsorbent, The high adsorption capacity （up to 212 mg/g） suggested a promising future as bimolecular hosts for the magnetic mesoporous silica.
