Nor-1α, 25-dihydroxy-22-oxo-vitamin D3 4 was synthesized by the coupling of known compound 5 and the A-ring phosphine oxide 6 followed by deprotection of the hydroxy functions.
Yong WU*1 Mei GUAN2 Pei Jie LI1 Cheng XU1 Xiao Chun WU1 1School of Pharmacy, West China University of Medical Sciences, Chengdu 610041 2The First Hospital, West China University of Medical Sciences, Chengdu 610041
The new shortcut synthesis route of(±)raphidecursinol 1,a racemic 8,4′-oxyneolignan compound,can be more easily achieved by the synthesis route,starting from readily available inexpensive 3,4,5-trimethoxybenzaldehyde and 1,2,3-trihydroxybenzene.All structures were confirmed by ~1H NMR,IR and MS.
Hua Jie YuanYao Yao ChengShan QianXiang XiaoYong Wu
An optically active intermediate 5 for A-ring of 19-nor-1a,25-dihydroxyvitamin D3 2 has been synthesized in five steps, starting from readily available, inexpensive D(+)-xylose 6 with good yield.
