Inclusion reaction of reaction 1, 1'-bi-2-naphthol and (S)-proline was examined uuder the solid state and the solid-liquid conditions. The results indicated that a solid mixture of racemic 1, 1'-bi-2-naphthol and (S)-proline in a 1 : 1 molar ratio was kept at 50-80 for 3-4 h, followed by treatment with benzene to give an insoluble solid and a benzene solution, from which (S)- (- )- and (R)-(+)-1, 1'-bi-2-naphthols of a modest level or optical purity were obtained. Arter 'kinetic' crystallization, both essentially enantiopure iso- mers were provided in 15%-35 % overall yields ,respectively.
Shan Zi-xing, Xiong Ying, Huang Shi-wen, Yun Hua-rong, Zhao De-jie College of Chemistry and Environmental Science, Wuhan University, Wuhan, 430072, China
