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国家自然科学基金(81071142)

作品数:7 被引量:45H指数:6
相关作者:王玮李强李玮朱佳王亚蓉更多>>
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发文基金:国家自然科学基金陕西省科技攻关计划陕西省卫生厅科学研究基金更多>>
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阿片类药物成瘾者基于杏仁核的Resting-state fMRI研究被引量:9
2012年
目的通过Resting-state fMRI探讨阿片类药物对杏仁核功能连接的影响。资料与方法阿片类药物成瘾患者12例,健康被试者14名(均为男性)。采用3.0 T磁共振扫描仪,对被试者分别进行静息态功能磁共振扫描,以双侧杏仁核为感兴趣区,分别进行功能连接分析,再将左右侧差异性脑区与阿片类药物成瘾组总吸毒时间、平均每日吸毒量等作相关分析。结果与对照组比较,阿片类药物成瘾者杏仁核与双侧海马旁回及双侧小脑半球功能连接度显著增强,与双侧楔前叶,左侧颞中、下回,左侧额中回功能连接度显著下降;左侧杏仁核和右侧楔前叶的功能连接度与阿片类成瘾者每日吸入量呈负相关。结论阿片类药物成瘾者认知控制功能的神经环路受损,而奖赏以及学习记忆环路功能出现异常强化。
吴宁李强李玮朱佳常海峰王玮
关键词:药物成瘾阿片类药物杏仁核磁共振成像
Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task被引量:12
2013年
Background Previous animal and neuroimaging studies have demonstrated that brain function in heroin addicted users is impaired. However, the posterior cingulate cortex (PCC) has not received much attention. The purpose of this study was to investigate whether chronic heroin use is associated with craving-related changes in the functional connectivity of the PCC of heroin addicted users. Methods Fourteen male adult chronic heroin users and fifteen age and gender-matched healthy subjects participated in the present study. The participants underwent a resting-state functional magnetic resonance imaging (fMRI) scan and a cue-induced craving task fMRI scan. The activated PCC was identified in the cue-induced craving task by means of a group contrast test. Functional connectivity was analyzed based on resting-state fMRI data in order to determine the correlation between brain regions. The relationship between the connectivity of specific regions and heroin dependence was investigated. Results The activation of PCC, bilateral anterior cingulate cortex, caudate, putamen, precuneus, and thalamus was significant in the heroin group compared to the healthy group in the cue-induced craving task. The detectable functional connectivity of the heroin users was stronger between the PCC and bilateral insula, bilateral dorsal striatum, right inferior parietal Iobule (IPL) and right supramarginal gyrus (P 〈0.001) compared to that of the healthy subjects in the resting-state data analysis. The strength of the functional connectivity, both for the PCC-insula (r=0.60, P 〈0.05) and for PCC-striatum (t=0.58, P 〈0.05), was positively correlated with the duration of heroin use. Conclusion The altered functional connectivity patterns in the PCC-insula and PCC-striatum areas may be regarded as biomarkers of brain damage severity in chronic heroin users.
LI QiangYANG Wei-chuanWANG Ya-rongHUANG Yu-fangLI WeiZHU JiaZHANG YiZHAO Li-yanQIN WeiYUAN KaiKaren M. von DeneenWANG WeiTIAN Jie
关键词:HEROINCRAVINGRESTING-STATE
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