Androgen deficiency is a physical disorder that not only affects adults but can also jeopardize children＇s health. Because there are many disadvantages to using traditional androgen replacement therapy, we have herein attempted to explore the use of human umbilical cord mesenchymal stem cells for the treatment of androgen deficiency. We transplanted CM-Dil-labeled human umbilical cord mesenchymal stem cells into the testes of an ethane dimethanesulfonate （EDS）-induced male rat hypogonadism model. Twenty-one days after transplantation, we found that blood testosterone levels in the therapy group were higher than that of the control group （P= 0.037）, and using immunohistochemistry and flow cytometry, we observed that some of the CM-Dil-labeled cells expressed Leydig cell markers for cytochrome P450, family 11, subfamily A, polypeptide 1, and 3-β-hydroxysteroid dehydrogenase. We then recovered these cells and observed that they were still able to proliferate in vitro. The present study shows that mesenchymal stem cells from human umbilical cord may constitute a promising therapeutic modality for the treatment of male hypogonadism patients.
Zhi-Yuan ZhangXiao-Yu XingGuan-Qun JuLiang ZhongJie Sun
目的总结睾丸下降不良并发萎缩的具体部位。方法通过检索1997年至2012年PubMed、EMBASE、Ovid、Web of Science及万方数据库，查找到8篇不能触及的隐睾的相关文献作为研究对象，统计分析先天性萎缩睾丸的发生部位。结果检索的8篇文献中，有208例患儿共210侧萎缩隐睾，其中腹腔内29侧，腹腔外181侧。结论萎缩隐睾绝大部分位于腹腔外。
