The Sichuan Basin is a superimposition basin composed of terrestrial and marine sediments that is well known for its abundant petroleum resources. Thermal history reconstruction using paleogeothermal indicators, including vitrinite reflectahoe and thermochronological data, shows that different structural subsections of the Sichuan Basin have experienced various paleogeothermal episodes since the Paleozoic. The lower structural subsection comprising the Lower Paleozoic to Middle Permian (Pz-P2) successions experienced a high paleogeothermal gradient (23.0-42.6℃/km) at the end of the Middle Permian (P2), whereas the upper structural subsection comprising Late Permian to Mesozoic strata underwent a relatively lower paleogeothermal gradient (13.2-26.9℃/km) at the beginning of the denudation (Late Cretaceous or Paleocene in the different regions). During the denudation period, the Sichuan Basin experienced a successive cooling episode. The high paleogeothermal gradient resulted from an intensive thermal event correlated to the Emeishan mantle plume. The heat flow value reached 124.0 mW/m2 in the southwestern basin near the center of the Emeishan large igneous province. The low geothermal gradient episode with heat flow ranging from 31.2 to 70.0 mW/m2 may be related to the foreland basin evolution. The cooling event is a result of the continuous uplift and denudation of the basin.