Prof.Liu Yong’s laboratory at the Institute for Nutrition Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,reported that the ER stress sensor IREl regulates fastinginduced metabolic adaptive programs through the XBPls-PPAR axis signaling in the liver,which was published in Nature Communications(2014,5:3528).The mammalian IRE1-XBP1 signaling branch of the cellular unfolded protein response plays a key role
