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国家自然科学基金(20571057)

作品数:11 被引量:46H指数:5
相关作者:胡茂林王卫东谭祥中尹萍陆江林更多>>
相关机构:温州大学湖北师范学院封开县江口中学更多>>
发文基金:国家自然科学基金温州市科技计划项目更多>>
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11 条 记 录,以下是 1-10
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5-氟尿嘧啶衍生物的研究进展被引量:15
2006年
5-氟尿嘧啶(5-FU)衍生物是临床上已为人们熟知的一类抗瘤广谱、有高效率的抗代谢药物。作为一种抗癌药物,它对多种肿瘤有抑制作用,所以5-氟尿嘧啶衍生物正受到化学界、医学界及生物学界的广泛关注。就目前国内外对5-氟尿嘧啶衍生物的研究进展做一概括和综述。
王卫东谭祥中胡茂林
关键词:5-氟尿嘧啶衍生物抗癌药物
Synthesis and Structural Characterization of a New Cadmium(Ⅱ) Complex Bridged by Endo-norbornene-cis-5,6-dicarboxylic Acid被引量:1
2007年
A polynuclear complex [Cd(endc)(H20)]n·nH2O (endc = endo-norbornene-cis- 5,6-dicarboxylate anion) has been synthesized by the hydrothermal reaction of cadmium nitrate tetrahydrate with endo-norbornene-cis-5,6-dicarboxylic acid in 1:1 molar ratio, and structurally characterized by single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/c with α = 1.16471(7), b = 0.95334(7), c = 0.91109(9) nm, Z= 4, V= 1.01035(14) nm^3, D, = 2.160 g/cm^3,μ = 2.172 mm^-1, F(000) = 648, R = 0.0302 and wR = 0.0752. According to structural analysis, each Cd(II) ion is coordinated to six O atoms from three endc anions and one water molecule, giving a distorted octahedral geometry. Two- dimensional layer arrangement of the title complex is constructed from the bridging nature of endc. It is worth notice that adjacent two-dimensional layers are joined together to form a three-dimensional supramolecular framework via intermolecular hydrogen bonding interactions.
蔡晓庆胡茂林陈帆
2-噻吩甲酸(5-氟尿嘧啶-1-基)甲酯的合成、晶体结构和热性质
2009年
报道了一种新的5-氟尿嘧啶衍生物2-噻吩甲酸(5-氟尿嘧啶-1-基)甲酯的合成.用1HNMR、13CNMR、IR对其进行了结构表征,通过单晶X射线衍射确定了晶体结构,同时分析了热性质.晶体属单斜晶系,空间群为P2/c,晶胞参数为:a=9.6134(14),b=4.8381(7),c=24.534(4),α=90°,β=97.289(3)°,γ=90°;Z=4,F(000)=552,R1=0.0616.
谢晓暖尤亮虞晓华胡茂林
关键词:5-氟尿嘧啶2-噻吩甲酸晶体结构热分析
铕(Ⅲ)-5-氟尿嘧啶-1-基乙酸-L-丝氨酸三元配合物的合成与性质被引量:9
2010年
在乙醇介质60℃水浴加热的条件下,合成了铕(Ⅲ)-5-氟尿嘧啶-1-基乙酸(5-Fu-1-yl)-L-丝氨酸(L-ser)三元固体稀土配合物,对其进行了元素分析、络合滴定、摩尔电导、紫外光谱、红外光谱、荧光光谱和循环伏安等性质的测试,确定其化学组成为[Eu(Ⅲ)(5-Fu-1-yl)(L-ser)]C l3.2H2O,重点通过循环伏安测定此配合物在碳糊工作电极上的电化学行为,在HAc-NaAc缓冲溶液(pH≈6.5)中,[Eu(5-Fu-1-yl)(L-ser)]C l3.2H2O和EuC l3在(-0.2)^(-1.2)V(vs.SCE)电位均表现出电化学活性,稀土配合物的电化学活化中心是Eu3+,且配合物的还原峰电流与浓度和扫描速度的平方根呈现很好的线性关系,说明该体系为标准的可逆体系。
王卫东陈亮林陈灵陆江林胡茂林
关键词:三元配合物红外光谱荧光光谱循环伏安
2-(甲苯-4-磺酰胺基)-苯甲酸的晶体结构、光谱及热性质(英文)被引量:4
2007年
报道了2-(甲苯-4-磺酰胺基)-苯甲酸(I)的元素分析和红外、核磁共振光谱性质并通过单晶X射线衍射确定了其晶体结构.晶体属单斜晶系,空间群为C2/c,晶胞参数为,a=2.7320(3)nm,b=0.85441(8)nm,c=1.17607(11)nm,!=90°,"=98.728(3)°,#=90°,V=2.7135(5)nm3,Z=8.晶体中分子单体通过N—H…O和O—H…O氢键作用形成具有中心对称的二聚体,且进一步通过两种不同的C—H…O氢键和$…$作用形成超分子结构.在不同的溶剂中,化合物I的紫外吸收表现出明显的溶剂效应,此外,荧光光谱与DSC-TGA热重分析表明,该化合物是一种耐热的荧光材料.
熊静蔡晓庆尹萍胡茂林
关键词:晶体结构溶剂效应
Synthesis and Crystal Structure of Tetraaquacopper(II) Bis(5-fluorouracil-1-acetate) Tetrahydrate被引量:6
2006年
The title compound, [Cu(C6H4N2O4F)2(H2O)4].4(H2O) I, has been hydrothermally synthesized and structurally determined by single-crystal X-ray diffraction method. It crystallizes in monoclinic, space group P21/c with a = 8.3041(17), b = 12.045(2), c = 11.077(2) A, β = 92.567(3)°, V= 1106.8(4) A^3, Mr = 581.89, Z= 2, Dc = 1.746 g/cm^3, F(000) = 598,μ(MoKa) = 1.090 mm^-1, the final R = 0.0296 and wR = 0.0806 for 3195 observed reflections with Ⅰ 〉 2σ(Ⅰ). In the centrosymmetric compound I, each Cu(Ⅱ) ion is coordinated by six O atoms from two 5-fluorouracil-1-acetate anions and four water molecules, forming a six-coordinated octahedral environment. N-H…O and O-H…O hydrogen-bonding interactions are observed in the structure, leading to the formation of a three-dimensional network.
WANG Wei-DongHU Mao-Lin
关键词:COPPER
α-(5-氟尿嘧啶-1-基甲基甲酰基)氨基-2-甲基戊酸的合成被引量:1
2009年
采用碳二亚胺法以5-氟尿嘧啶-1-基乙酸、二环已基碳二酰亚胺和L-亮氨酸为原料,1-羟基苯并三氮唑为辅助试剂,通过液相偶联法合成了一种新型的α-(5-氟尿嘧啶-1-基甲基甲酰基)氨基-2-甲基戊酸化合物。通过红外光谱、元素分析和核磁共振氢谱等确证了其结构。
王卫东吴振陆江林胡茂林
关键词:L-亮氨酸
Hydrothermal Synthesis and Crystal Structure of a Novel Polymolybdic(VI) Acid: {[H_3O]_2^+[Mo_2O_4(OH)_6]^(2-)}_n
2006年
A novel supramolecular polymolybdic(VI) acid was unexpectedly synthesized by the reaction of sodium molybdate with 1,2,4,5-benzenetetracarboxylic and trichloroacetic acids in 1:1:1 molar ratio under hydrothermal condition. The crystal belongs to tetragonal with space group P4/mbm, a = 0.88867(17), b = 0.88867(17), c = 0.55676(15) nm, Z = 3, V = 0.43969(17) nm^3, Dc = 4.486 g/cm^3,μ = 4.365 mm^-1, F(000) = 576, R = 0.0273 and wR = 0.0679. In the crystal, the Mo(VI) atoms are six- and five-coordinated in distorted octahedral and trigonal bipyramidal geometries, respectively. Furthermore, these Mo(VI) atoms, bearing different coordinated environments, are bridged by OH groups with disorder O atoms to form a twodimensional framework with pentagonal grids. It is worthy of notice that these adjacent twodimensional frameworks are extended into a three-dimensional supramolecular array with pentagonal large cavities'by Van Der Waals' forces and hydrogen bonding interactions.
WANG Wei-DongHU Mao-Lin
α-(5-氟尿嘧啶-1-基甲基甲酰基)氨基戊二酸的合成与表征被引量:10
2006年
以5-氟尿嘧啶-1-基乙酸、二环己基碳二酰亚胺和L-谷氨酸为原料,用1-羟基苯并三氮唑(BtOH)作辅助试剂,采用碳二亚胺法并通过液相偶联合成了标题化合物,收率为81.5%。通过红外光谱、元素分析确证了该种“5-氟尿嘧啶短肽化合物”的结构。
王卫东谭祥中胡茂林
关键词:5-氟尿嘧啶氨基酸
Hydrothermal Synthesis, Crystal Structure, and Characterization of a Novel Terbium(Ⅲ) Coordination Polymer Bridged by 5-Sulfoisophthalate Trivalent Anions
2007年
Hydrothermal reaction of terbium( Ⅲ) chloride with 5-sulfoisophthalic acid monosodium salt and 1,10-phenanthroline(phen) at 415 K resulted in the formation of a novel coordination polymer, [ Tb (sip) (phen) (H2O) ],(sip =5-sulfoisophthalate trivalent anion) with a three-dimensional network structure. Each centrosymmetrically related pair of terbium ions axe linked by two sip anions, forming a binuclear unit, and each binuclear unit links to four adjacent tetranuclear units, extending a two-dimensional hybrid layer at crystallographic bc plane. On the other hand, every three-terbium ion is connected by three sip anions, generating a trinuclear ring, and the trinuclear ring connects six neighboring trinuclear rings to produce another two-dimensional layer at crystallographic ab plane. Moreover, each sip anion acts as a pontadentate bridge, interconnecting two different types of layers to yield a novel three-dimensional framework.
YUAN Ji-xin XIONG Jing
关键词:TERBIUM
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