The earthquake mitigation effect of hysteretic dampers is not only related to the number, stiffness, strength, deformation ability of dampers but also to the strength and stiffness of the structure. This paper studied the condition that structures should be in when the hysteretic dampers mitigated seismic action most effectively and made appropriate numerical analysis to verify the effectiveness of theory derivation. The inelastic seismic responses were analyzed for the SDOF system that the shear strength ratio of the damper system was taken differently and the result showed that when the ratio was in the vicinity of the optimum strength ratio of the damper system, the displacement of the structure was minimum and the energy dissipation of dampers was maximum, which indicated that the dampers mitigated seismic action most effectively. The result also indicated that the hysteretic dampers had significant earthquake mitigation effect when the strength ratio β changed in a relatively wide range.