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国家自然科学基金(30972939)

作品数:2 被引量:2H指数:1
相关作者:姚凡陈波金锋刘彩刚更多>>
相关机构:中国医科大学附属第一医院更多>>
发文基金:国家自然科学基金辽宁省教育厅高等学校科学研究项目辽宁省博士科研启动基金更多>>
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Comparison of surgical methods and prognostic factors in T4 gastric cancer
2010年
Objective: In advanced gastric carcinomas that have invaded adjacent organs, the prognosis is poor. When combined resections are performed in T4 gastric cancers, it is inconclusive as to whether or not there is an improvement in the survival rate. We compared with gastrectomy alone to analyze the prognostic factors in T4 gastric cancers. Methods: Between January 1997 and December 2004, 115 patients underwent surgery for T4 gastric cancer; we divided them into two groups: combined resections in group Ⅰ, gastrectomy alone in group Ⅱ. Surgical outcomes and clinicopathologic factors were compared and prognostic factors were evaluated. Results: Among the two groups, statistically significantly different factor was Borrmann type. The most commonly resected organ was the transverse colon, and no one post-operative morbidities developed. In the multivariate analysis, the treatment group and curability were proved to be independent prognostic factors. Conclusion: In patients with T4 gastric carcinoma, surgical gastrectomy alone approach can be beneficial. Compared with the group I, non-resection (gastrectomy alone) can be performed for a better surgical approach.
Latengbaolide A
beclin-1基因在乳腺癌中的表达及其与临床病理因素的关系被引量:2
2009年
目的探讨beclin-1基因在乳腺癌中的表达及其与临床病理因素的关系。方法采用实时定量PCR和免疫组化方法检测56例乳腺癌中beclin-1基因及蛋白的表达并分析其与临床病理因素的关系。结果beclin-1mRNA及蛋白在乳腺癌中的表达显著下调,但与临床病理因素无显著相关性。结论beclin-1可能在乳腺癌中负调控而引起肿瘤的发生。
陈波金锋姚凡刘彩刚
关键词:乳腺癌实时定量PCR免疫组化
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