The title complex（C66H76O8·CH3CN） was synthesized and structurally determined by single-crystal X-ray diffraction method. It crystallizes in monoclinic, space group P21/c with a = 22.384（13）, b = 13.413（7）, c = 21.867（12）, β = 112.257（7）°, C68H78NO8, Mr = 1037.31, Dc = 1.133 g/cm3, V = 6076（6） 3, Z = 4, F（000） = 2224, μ（MoKa） = 0.073 mm-1, T = 296（2） K, 10276 independent reflections with 5469 observed ones（I 〉 2σ（I））, R = 0.0797 and wR = 0.2316 with GOF = 1.027（R = 0.1442 and wR = 0.2689 for all data）. The calixarene moiety maintains the symmetric cone conformation through intramolecular O–H···O hydrogen bonds. The inhibition of the strand transfer process of HIV-1 integrase of the title compound was also evaluated. Preliminary bioassays indicated that it has a low inhibition ratio（24.85%） at the concentration of 50 μM.
The title compound （C50H.44010） was synthesized and structurally determined by single-crystal X-ray diffraction method. It crystallizes in monoclinic, space group P21/c with a = 16.713（4）, b --- 13.189（3）, c = 19.434（5） A, β = 104.411（4）°, Mr = 804.85, Dc = 1.288 g/cm3, V = 4149.2（17） A3, Z = 4, F（000） = 1696, #（MoKa） = 0.089 mm-1T = 296（2） K, 7279 independent reflections with 3172 observed ones （I 〉 2δ（/））, R = 0.0520 and wR = 0.1203 with GOF = 0.928 （R = 0.1464 and wR = 0.1657 for all data）. The calixarene moiety maintains the symmetric cone conformation through intramolecular O-H…O hydrogen bonds. Preliminary bioassays indicated that the title compound has a potent inhibitory activity against the strand transfer process of HIV-1 integrase.
The target compound （C58H74N6010） has been structurally determined by single- crystal X-ray diffraction. The crystal is in the monoclinic system, space group C2/c, with a = 22.08（3）, b = 12.628（19）, c- 21.73（3）A, β= 106.78（3）°, C58H74N6010, Mr= 1015.23, Dc = 1.16239 g/cm^3, V = 5801（14） A3, Z = 4, F（000） = 2176, μ（MoKa） = 0.080 mm^-1, T = 293（2） K, 5107 independent reflections with 3125 observed ones （1〉 20（I））, R = 0.0768 and wR = 0.2305 with GOF = 1.025 （R = 0.1129 and wR = 0.2674 for all data）. The calixarene moiety maintains the symmetric cone conformation through intramolecular O-H…O and N-H…O hydrogen bonds. The thermal analysis showed that the decomposition mechanism of compound 3 is complex. Fluorescence spectra of 3 exhibited an emission band at 423 nm when excited with 360 nm radiation at room temperature in DMF.
