Objective:To investigate the effect of Modified Zhuye Shigao Decoction(加味竹叶石膏汤,MZSD)and its components on preventing radiation esophagitis of rats.Methods:One hundred Wistar rats were randomly divided into 5 groups,including the control group,radiation model group,MZSD group,Zhuye Shigeo Decoction(竹叶石膏汤,ZSD)group,and added Ingredients group,20 rats in each group.The model of radiation esophagitis of rat was established by once local radiation of 40 Gy(330 Mulmin)with a high energy linear accelerator.The administration of Chinese medicine was continued for 14 days from 7 days before radiation application in the three treatment groups.On the 7th and 14th day,the serum was isolated and the levels of inflammatory cytoldnes tumor necrosis factor(TNF-α),interleukin 1 13(IL-1β)and IL-8 were tested.The pathological slices of esophagus were obtained,and the pathological changes were observed.During the whole process,weight and food intake were recorded each day.Results:On the 7th day after radiation,the esophagus of rats in the MZSD group was almost intact,and the pathological injury score was significantly lower than that of the radiation model group,ZSD group and added ingredients group(P<0.01).Compared with the control group,the body weight and food intake of rats in the radiation model group were significantly decreased,and the levels of TNF-α,IL-1β and IL-8 were significantly increased(P<0.05 or P<0.01),while the MZSD group showed a significant increase in body weight and food intake,and a significant decrease in the levels of TNF-α,IL-1β and IL-8 compared with the radiation model group,ZSD group and added ingredients group(P<0.05 or P<0.01).Conclusion:MZSD prevents the development of radiation esophagitis probably by inhibiting the generation and release of the inflammatory cytoldnes TNF-α,IL-1β and IL-8.
OBJECTIVE:To systematically assess the clinical effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis by meta-analysis.METHODS:The articles were mainly retrieved from the "CHKD(China Hospital Knowledge Database) periodical full text databank",the "China periodical full text databank",the "CHKD doctor's and Master's degree student full text databank",and the "China doctor's degree student thesis databank",and they were selected according to the literature selection standard.The effects of Chinese medicines and Western medicines on radiation esophagitis were compared by meta-analysis.RESULTS:Based on 13 articles,we found that the effectiveness of Chinese medicines for prevention and treatment of radiation esophagitis was superior to Western medicines,with no obvious side effects.Meta-analysis showed that the total odds ratio was 0.426 and the 95% confidence interval was 0.368,0.493.CONCLUSION:Chinese medicines are superior to Western medicines in preventing and treating radiation esophagitis.However,some methodological problems in the literature may have affected the authenticity of the results.Therefore,more rigorous,multi-central,randomized controlled trials with a large sample size should be designed to obtain a more reliable conclusion.
