On Nov 24,2009,the Proceedings of the National Academy of Sciences published online a research article from ION entitled'PKCδRegulates Cortical Radial Migration by Stabilizing the Cdk5 Activator P35'.This work was carried out by graduate students Chun-tao Zhao,Kun Li,Wang Zheng,Jun-tao Li, Xun-jun Liang,An-qi Geng and Ning Li from the laboratory of Dr.Xiao-bing Yuan.
Proper migration of neuronal somas and axonal growth cones to designated locations in the developing brain is essential for the assembly of functional neuronal circuits.Rapid progress in research of axon guidance and neuronal migration has been made in the last twenty years.Chinese researchers began their exploration in this field ten years ago and have made significant contributions in clarifying the signal transduction of axon guidance and neuronal migration.Several unique experimental approaches,including the migration assay of single isolated neurons in response to locally delivered guidance cues,have been developed by Chinese neuroscientists to investigate the molecular machinery underlying these guidance events.
YUAN XiaoBing Institute of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China
