家蚕二分浓核病毒(Bombyx mori bidensovirus,BmBDV)归属于新设定的二分DNA病毒科二分浓核病毒属,该病毒曾归属于细小病毒科浓核病毒亚科,主要在家蚕中肠柱状细胞内复制,并引起严重的软化病.与细小病毒不同的是,这种病毒的基因组包含两个节段的单链DNA并编码一个以蛋白为引物的DNA聚合酶.越来越多的证据表明该病毒不同于细小病毒,并采用独特的机制进行复制,到目前为止,该病毒的复制机制尚未明了.本文主要综述了该病毒的病理学和病毒生物学方面的研究进展,包括病毒的基因,基因组结构,以及病毒表达复制方式.
Bombyx mori bidensovirus(BmBDV),which had been assigned to Densovirinae in Parvoviridae previously,replicates mainly in silkworm midgut columnar cells and causes the fatal flacheric disease.In contrast to parvovirus,this virus possesses two single-stranded DNA genome segments and encodes a putative protein-primed DNA polymerase.The accumulating evidence suggests that it has unique characteristics different to parvovirus and adopts its own mechanisms for replication.So far,little is known about the replication mechanisms of BmBDV.In this review,we focus on the pathology associated with this virus and the viral biology such as viral genome structure,viral genes,and viral replication and expression strategies.
HU ZhaoYangLI GuoHuiLI GuangTianYAO QinCHEN KePing
