Tip vortex cavitation is the first type of cavita- tion to take place around most marine propellers. But the numerical prediction of tip vortex cavitation is one of the challenges for propeller wake because of turbulence dis- sipation during the numerical simulation. Several parame- ters of computational mesh and numerical algorithm are tested by mean of the predicted length of tip vortex cav- tiation to validate a developed method. The predicted length of tip vortex cavtiation is on the increase about 0.4 propeller diameters using the developed numerical method. The predicted length of tip vortex cavtiation by RNG k - e model is about 3 times of that by SST k - ~o model. Therefore, based on the validation of the present approach, the cavitating flows generated by two rotating propellers under a non-uniform inflow are calculated further. The distributions of axial velocity, total pressure and vapor volume fraction in the transversal planes across tip vortex region are shown to be useful in analyzing the feature of the cavitating flow. The strongest kemel of tip vortex cavitation is not at the position most close to blade tip but slightly far away from the region. During the growth of tip vortex cavitation extension, it appears short and thick, and then it becomes long and thin. The pressure fluctuations at the positions inside tip vortex region also validates the conclusion. A key finding of the study is that the grids constructed especially for tip vortex flows by usingseparated computational domain is capable of decreasing the turbulence dissipation and correctly capturing the fea- ture of propeller tip vortex cavitation under uniform and non-uniform inflows. The turbulence model and advanced grids is important to predict tip vortex cavitation.