A unique transformation to realize the allylic amination from vinylic bromides was described and an unexpected C-Pd migration was observed from sp2 carbon to adjacent allylic sp3 carbon initiated from vinyl bromide. Various 3-aryl-2-bromopropenes and secondary amines were surveyed and the allyl amination products were obtained in moderate isolated yields. The primary amine was not fit for this transformation. Mechanistic studies indicate that this migration went through β-hydride elimination and reverse C=C bond insertion.
＜正＞Direct functionalization of indole derivatives has attracted great attention due to the importance of the p...
Yang Li,Wen-Hua Wang,Shang-Dong Yang,Bi-Jie Li,Chun Feng and Zhang-Jie Shi~* Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry,Peking University,Beijing,100871,China.
＜正＞Many methods have been developed to regioselctively functionalize indole derivatives at C2 and/or C3 positi...
Wen-Hua Wang,Yang Li and Zhang-Jie Shi~* Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry,Peking University,Beijing,100871,China
