Considering the effect of viscosity-temperature relationship and cavitation of micro-scale film,the influencing factors on hydrodynamic lubrication performance of upstream pumping mechanical seal were investigated based on the theory of hydrodynamic lubrication.N-S equation,energy equation,viscosity-temperature equation and vapor transport equation were solved with the finite volume method by using Fluent software,which was performed to analyze the influence of the viscosity-temperature and cavitation effect on hydrodynamic lubrication failure of the film.The research demonstrates that it will lead to the significant difference of the temperature field by considering the coupling of temperature and viscosity.When the film thickness decreases and the rotating speed rises,cavitation regions and viscous friction heat increases,the opening force of the film is also enhanced.However,the growth rate is restricted to the cavitation regions and viscous friction heat,and the opening force begins to decline to a certain extent,and thereby being insufficient to open the surfaces of the seals and leading to the failure of automatic adjustment function and severe wear,lubrication failure occurrs.Through comprehensive research on the influences of viscosity-temperature and cavitation effect on hydrodynamic lubrication performance,the theories of failure and design of upstream pumping mechanical seal are further developed.