Hot-compression of aluminum alloy 5182 was carried out on a Gleeble- 1500 thermo-simulator at deformation temperature ranging from 350 ℃ to 500 ℃ and at strain rate from 0.01 s^-1 to 10 s^-1 with strain range from 0.7 to 1.9. The microstructures and macro-textures evolution under different conditions were investigated by polarized optical microscopy and X-ray diffraction analysis, respectively. The basic trend is that the hot-compression stress increases with the decrease of temperature and increase of strain rate, which is revealed and elucidated in terms of Zener-Hollomon parameter in the hyperbolic sine equation with the hot-deformation activation energy of 143.5 kJ/mol. An empirical constitutive equation is proposed to predict the hot-deformation behavior under different conditions. As deformation temperature increases up to 400 ℃, at strain rate over 1 s^-1, dynamic recrystallization (DRX) occurs. Cube orientation { 100} (001) is detected in the recrystallized sample after hot-compression.