Hot-compression of aluminum alloy 5182 was carried out on a Gleeble-1500 thermo-simulator at deformation temperatureranging from 350 °C to 500 °C and at strain rate from 0.01 s 1to 10 s 1with strain range from 0.7 to 1.9. The microstructures andmacro-textures evolution under different conditions were investigated by polarized optical microscopy and X-ray diffraction analysis,respectively. The basic trend is that the hot-compression stress increases with the decrease of temperature and increase of strain rate,which is revealed and elucidated in terms of Zener-Hollomon parameter in the hyperbolic sine equation with the hot-deformationactivation energy of 143.5 kJ/mol. An empirical constitutive equation is proposed to predict the hot-deformation behavior underdifferent conditions. As deformation temperature increases up to 400 °C, at strain rate over 1 s 1, dynamic recrystallization (DRX)occurs. Cube orientation {100} 001 is detected in the recrystallized sample after hot-compression.