Bacterial infections are a major cause of chronic infections.Thus,antibacterial material is an urgent need in clinics.Antibacterial nanofibers,with expansive surface area,enable efficient incorporation of antibacterial agents.Meanwhile,structure similar to the extracellular matrix can accelerate cell growth.Electrospinning,the most widely used technique to fabricate nanofiber,is often used in many biomedical applications including drug delivery,regenerative medicine,wound healing and so on.Thus,this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue me-dicinal fields.This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue.Finally,we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.
Zhimei WeiLiqun WangShouyu ZhangTonghai ChenJie YangShengru LongXiaojun Wang
Poly(decamethylene terephthalamide/decamethylene isophthalamide)-block-polyvinyl alcoho)(PA10 T/10 IPEG) copolymer/graphene oxide(GO) composites were prepared via in-situ melt polymerization and two different nano-filler addition approaches were compared. The relationship between the micro-structure and performance of the elastomer composites prepared by one-step and two-step methods was explored. The results show that the two-step method significantly promoted the dispersion of the GO in a polymer matrix, and facilitated the grafting of more hard molecular chains. Thus, the elastic modulus and tensile strength of the nanocomposite have been significantly improved by the presence of GO. This was because of the strong interaction between the functional groups on the surface of the GO and the hard molecular chains. This would be also be favorable to load transfer across the interface. Additionally, the elongation at the break of composites increased by 10% with the addition of a small amount of GO(0.2% wt). This is because hard domains tend to be enriched on the surface of GO in composites and act as a lubricating layer at the interface between the GO and matrix, leading to increased deformation ability. This work provides an effective strategy to prepare elastomer composites with high strength and toughness.
Xiao-bo FuXin TongJia-cao YangGang ZhangMei-lin ZhangXiao-jun WangJie Yang
Poly(arylene sulfide sulfone)/graphene nanoplate(PASS/GNP) composites with segregated structure based on continuous polymer fiber skeletons were fabricated by coating a thin conductive layer on the PASS fibers and then performing compression molding. The formation of a unique segregated conductive network endowed the PASS/GNP composites with high electrical conductivity and excellent electromagnetic interference(EMI) shielding effectiveness(SE), reaching 17.8 S/m and 30.1 d B, respectively, when the content of the GNPs in the conductive layer was 20 wt%. The PASS/GNP composites also exhibited outstanding mechanical properties, which was attributed to the continuous PASS fiber skeletons that could withstand large loads and the strong interfacial interaction between the conductive layers and the PASS fibers that could provide good stress transfer. This approach is suitable for most soluble polymers.
Cheng-gong ChangJia-cao YangGang ZhangSheng-ru LongXiao-jun WangJie Yang
Tissue engineering has become a hot issue for skin wound healing because it can be used as an alternative treatment to traditional grafts.Nanofibrous films have been widely used due to their excellent properties.In this work,an organic/inorganic composite poly(arylene sulfide sulfone)/ZnO/graphene oxide(PASS/ZnO/GO)nanofibrous film was fabricated with the ZnO nano-particles blending in an electrospun solution and post-treated with the GO deposition.The optimal PASS/ZnO/GO nanofibrous film was prepared by 2%ZnO nanoparticles,3.0g/mL PASS electrospun solution,and 1%GO dispersion solution.The morphology,hydrophilicity,mechanical property,and cytotoxicity of the PASS/ZnO/GO nanofibrous film were character-ized by using scanning electron microscopy,transmission electron microscope,water contact angle,tensile testing,and a Live/Dead cell staining kit.It is founded that the PASS/ZnO/GO nanofibrous film has outstanding mechanical properties and no cytotoxicity.Furthermore,the PASS/ZnO/GO nanofibrous film exhibits excellent antibacterial activity to both Escherichia coli and Staphylococcus aureus.Above all,this high mechanical property in the non-toxic and antibacterial nanofibrous film will have excellent application prospects in skin wound dressing.
Xuzhi LangZhurong TangZhimei WeiXiaojun WangShengru LongGang ZhangJie YangQingyu Lin
