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国家自然科学基金(81200936)

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Intraoperative ultrasound assistance in resection of intracranial meningiomas被引量:3
2013年
Objective: Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due to their complicated anatomy structures and adjacent vessels. It's essential to locate the tumor and its vessels precisely during operation to reduce the risk of neurological deficits. The purpose of this study was to evaluate intraoperative ultrasonography in displaying intracranial meningioma and its surrounding arteries, and evaluate its potential to improve surgical precision and minimize surgical trauma. Methods: Between December 2011 and January 2013, 20 patients with anterior and middle skull base meningioma underwent surgery with the assistance of intraoperative ultrasonography in the Neurosurgery Department of Shanghai Huashan Hospital. There were 7 male and 13 female patients, aged from 31 to 66 years old. Their sonographic features were analyzed and the advantages of intraoperative ultrasonography were discussed. Results: The border of the meningioma and its adjacent vessels could be exhibited on intraoperative ultrasonography. The sonographic visualization allowed the neurosurgeon to choose an appropriate approach before the operation. In addition, intraoperative ultrasonography could inform neurosurgeons about the location of the tumor, its relation to the surrounding arteries during the operation, thus these essential arteries could be protected carefully. Conclusions: Intraoperative ultrasonography is a useful intraoperative technique. When appropriately applied to assist surgical procedures for intracranial meningioma, it could offer very important intraoperative information (such as the tumor supplying vessels) that helps to improve surgical resection and therefore might reduce the postoperative morbidity.
Hailiang TangHuaping SunLiqian XieQisheng TangYe GongYing MaoQing XieMingzhe ZhengDaijun WangHongda ZhuJianhong ZhuXiaoyuan FengZhenwei YaoXiancheng ChenLiangfu Zhou
关键词:脑膜瘤手术创伤神经外科神经功能
Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital被引量:6
2013年
Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods: 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results: Among the 15 cases (10 males and 5 females), the age ranged from 22 to 74 years old (the mean age was 50.67-year old). The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions: Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients.
Hailiang TangHuaping SunHong ChenYe GongYing MaoQing XieLiqian XieMingzhe ZhengDaijun WangHongda ZhuXiaoming ChePing ZhongKang ZhengShiqi LiWeimin BaoJianhong ZhuXuanchun WangXiaoyuan FengXiancheng ChenLiangfu Zhou
关键词:病理分析脑膜瘤平均年龄
Home visits in brain tumor patient: how nurse and family members cooperate in tumor patient's family self-care被引量:2
2013年
Purposes:We reported the roles and functions of nurses in home visits for brain tumor patients using the family health assessment guide in the study.Methods:One patient of brain glioma was chosen as the case illustration.The nurses assessed the patients’situation,their families and living environment individually.All these factors were analyzed together.Results:The nurses then implemented their knowledge and skills to adopt different measures in different conditions,investigated the patients’health problems and carried out personalized effective actions.Conclusions:Nurses should put effort into community nursing to allow patients to live in a safe environment,to satisfy the health needs of human being and their needs for health knowledge,and enhance their self-care abilities.
Liwei LangZhiyue YanHailiang Tang
关键词:肿瘤病
Application of CUSA Excel ultrasonic aspiration system in resection of skull base meningiomas被引量:3
2014年
Background: Effective methods for managing patients with solitary pulmonary nodules(SPNs) depend critically on the predictive probability of malignancy.Methods: Between July 2009 and June 2011, data on gender, age, cancer history, tumor familial history, smoking status, tumor location, nodule size, spiculation, calcification, the tumor border, and the final pathological diagnosis were collected retrospectively from 154 surgical patients with an SPN measuring 3-30 mm. Each final diagnosis was compared with the probability calculated by three predicted models—the Mayo, VA, and Peking University(PU) models. The accuracy of each model was assessed using area under the receiver operating characteristics(ROC) and calibration curves.Results: The area under the ROC curve of the PU model [0.800; 95% confidence interval(CI): 0.708-0.891] was higher than that of the Mayo model(0.753; 95% CI: 0.650-0.857) or VA model(0.728; 95% CI: 0.623-0.833); however, this finding was not statistically significant. To varying degrees, calibration curves showed that all three models overestimated malignancy.Conclusions: The three predicted models have similar accuracy for prediction of SPN malignancy, although the accuracy is not sufficient. For Chinese patients, the PU model may has greater predictive power.Background: Here, we introduced our short experience on the application of a new CUSA Excel ultrasonic aspiration system, which was provided by Integra Lifesciences corporation, in skull base meningiomas resection.Methods: Ten patients with anterior, middle skull base and sphenoid ridge meningioma were operated using the CUSA Excel ultrasonic aspiration system at the Neurosurgery Department of Shanghai Huashan Hospital from August 2014 to October 2014. There were six male and four female patients, aged from 38 to 61 years old(the mean age was 48.5 years old). Five cases with tumor located at anterior skull base, three cases with tumor on middle skull base, and two cases with tumor on sphenoid ridge.Results: All the patents received t
Hailiang TangHaishi ZhangQing XieYe GongMingzhe ZhengDaijun WangHongda ZhuXiancheng ChenLiangfu Zhou
关键词:EXCEL细胞周期蛋白D1WESTERN印迹RNAI技术
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