Female Wister rats aged 8 weeks were randomly divided into sham operation group,ovariectomized(OVX)control group,and 2 OVX groups fed with soy isoflavone crude extract supplementation.The rats had free access to high fat diet and water for 9 weeks.No significant difference was found in body weight(BW),total abdominal fat,food intake and food utilization rate between OVX control group and 2 OVX groups.However,the fasting blood glucose and blood lipid levels were significantly higher in 2 OVX groups than in OVX control group(P<0.05).Intraperitoneal glucose tolerance test(IGTT)showed that the area under AUC was smaller in 2 OVX groups than in OVX control group(P<0.05).These findings showed that soy isoflavone crude extract supplementation can improve glucose tolerance and prevent high fat diet-induced insulin resistance in ovariectomized rats.
ZHANG Yun BoLI Li NaZHAO Xin YuCHEN Wen HuaGUO Jing JingFU Zheng HaiYANG YangNA Xiao Lin
Female Sprague-Dawley rats weighing 60-80 g were given different dosages of soy isoflavones and/or lindane for four weeks.Soy isoflavones was added in feed and lindane was given by oral gavage.We found that soy isoflavones could reduce the level of lindane in rat’s serum and brain,but might cause the uterus hyperplasia.Lindane could inhibit the effect of soy isoflavones on uterus and
YANG YangZHANG Yun BoSHENG WeiFU Zheng HaiWANG ZheWANG XiaoGUAN Si YuanNA Xiao Lin
