Industry-city integration in industrial park has stepped into quick development with the continuous advancement of urbanization in China. Relying on the developed ecological industry chain,sustainable development ability and good ecological service,eco-industrial park is at the forefront of industry-city integration,and accumulates rich experience in practice. The operation mechanism model includes government development,development of large state-owned enterprises,and public-private partnership. The space structures involve the relation between central urban district and new industrial town,overall layout of production,living and ecological space in eco-industrial park. In the aspect of system innovation,park management system,household registration management system,cultural system of community and environmental governance system face the challenges.