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上海市浦江人才计划项目(07pj14062)

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Characteristics of Obesity and Its Related Disorders in China被引量:46
2010年
Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences. Abdominal obesity, also known as central obesity, refers to the presence of excess fat in the abdominal area. Obesity, especially abdominal obesity, contributes to many metabolic disorders including metabolic syndrome (MetS), type 2 diabetes (T2DM) and cardiovascular diseases (CVD). The incidence of obesity has increased dramaticaUy in recent yeats worldwide. In China, more than one-third of adults are overweight or obese and 10%-20% of all adults are affected by MetS. The pathogenesis underlying the abdominal obesity remains unclear. The ultimate health outcome of obesity and its related metabolic disorders have prompted physicians to take aggressive treatments (lifestyle changes, pharmacological interventions and surgical therapies) before a serious consequence becomes clinically apparent. In this review, we discuss the prevalence, pathogenesis and clinic features of obesity in China.
WEI-PING JIA ,CHEN WANG,SHAN JIANG,AND JIE-MIN PAN Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai Diabetes Institute,Shanghai Clinical Center of Diabetes,Shanghai 200233,China
关键词:OBESITY
生长因子受体结合蛋白10与糖尿病被引量:1
2009年
李羚贾伟平王琛
关键词:生长因子受体结合蛋白基因敲除技术生长发育障碍PROTEIN单核苷酸多态性
APPL1与胰岛素抵抗被引量:2
2009年
Adaptor protein containing PH domain,PTB domain and leucine zipper motif 1(APPL1)是一种具有多个功能结构域的细胞内转接蛋白,包含PH结构域、PTB结构域以及亮氨酸拉链基序。研究发现,APPL1可与多个蛋白结合,参与细胞内多条信号转导通路,与前列腺癌、结肠癌、神经系统相关疾病以及排卵等过程有关。
朱云霞王琛贾伟平
关键词:胰岛素抵抗PH结构域PROTEIN信号转导通路蛋白结合亮氨酸拉链
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