An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow microreactor.The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT assay.Compounds 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.
