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Design and synthesis of analogues of α-galactosylceramide as novel immunomodulators: <正>Invariant natural killer T(iN KT)cells are regulatory T cells that play an important role in tumor immunity...; Jingjing BiWeiwei MaGuisheng Zhangyuguo Du; 文献传递

Copper Mediated Sequential C-N and N-N Bond Formation:Facile Synthesis of Symmetrical-1,2,4-triazoles: 1,2,4-Triazole-containing compounds are widely used in pesticides[1], plant growth regulators[2], medicines[3]...; Zhang,ZhiguoLi,ZhonglianZhang,WeiLiu,Qingfeng; 关键词：COPPER AMIDINE HYDROCHLORIDE

Selenium-catalyzed oxidative carbonylation of 2-aminobenzyl alcohol to give 1,4-dihydro-2H-3,1-benzoxazin-2-one被引量：1: 2016年; An efficient,economical,and phosgene-free approach was developed for the preparation of l,4-dihydro-2H-3,l-benzoxazin-2-one from 2-aminobenzyl alcohol.In terms of its key features,this reaction uses the cheap and recyclable non-metal selenium as a catalyst instead of the noble metal palladium;carbon monoxide as a carbonylation agent instead of virulent phosgene or one of its derivatives;and oxygen as an oxidant.The selenium-catalyzed oxidative carbonylation reaction of2-aminobenzyl alcohol proceeded efficiently in a single pot in the presence of triethylamine to afford l,4-dihydro-2H-3,l-benzoxazin-2-one in 87%yield.Furthermore,the selenium catalyst was readily recovered and recycled,affording a product yield of 80%after five cycles.; 张晓鹏王平牛雪利李政伟范学森张贵生; 关键词：SELENIUM

Dimerization of Acetoacetanilides:Facile Synthesis of Polysubstituted 4-Pyridones: 4-Pyridone derivatives were identified as potent inhibitors of FabI,the enoyl-acyl carrier protein reductase i...; Zhiguo ZhangFang ShiliangQingfeng LiuGuisheng Zhang; 关键词：DIMERIZATION ACYL CONDENSATION

降血脂药阿托伐他汀钙的合成新工艺研究: 阿托伐他汀钙是HMG - CoA还原酶抑制剂,适用于各型高胆固醇血症和混合型高脂血症.我们采取汇聚法合成主环,分别以苯乙酰氯和甲基异丙酮为起始原料,应用了经典的傅克酰基化反应,自由基反应、克莱森缩合反应等,最后由合成4-...; 马玉坤李伟王连明张贵生; 关键词：HMG-COA还原酶抑制剂阿托伐他汀钙

高价碘试剂促进的N-芳基磺酰胺类化合物脱芳基反应被引量：1: 2020年; 通过高选择性惰性磺酰胺芳基C—N键裂解反应,发展了一种Dess-Martin氧化剂(DMP)促进的N-芳基磺酰胺的脱芳基的方法.该无金属参与的反应在温和的条件下进行,可提供各种在生物学上有重要应用价值的伯磺酰胺类化合物,其中某些磺酰胺使用传统的氨解和水解方法难以获得.这一简单有效的脱芳基反应可在无金属催化剂条件下使芳基作为磺酰胺类化合物的氨基保护基.; 宋蒙蒙张志国郑丹李祥梁蕊赵旭娜时蕾张贵生; 关键词：磺酰胺

Iron-catalyzed Multicomponent Tandem Reaction of Biginelli Reaction/Vinylogous Aldol Condensation As a Strategy for the Synthesis of (E)-6-Arylvinyl-3,4-dihydropyrimidin-2(1H)-ones: Dihydro-pyrmidinones(DHPMs) and their derivatives have attracted considerable interest recently because they e...; Zhang,ZhiguoZhang,LianqiangLiu,Qingfeng; 关键词：MULTICOMPONENT REACTION CATALYZED BIGINELLI REACTION ALDOL CONDENSATION

Study On the Electrophilic Fluorination of Acetacetamides Under Green Conditions: 含氟化合物扮演着越来越重要的角色,引入氟原子的化合物往往表现出特殊的性质,因此他们被广泛应用于药物化学,农药化学和材料化学.1 尤其是2-单氟代二羰基化合物广泛的应用于不对称合成2-5 和生物活性化合物合成.6,7 以工...; Jingjing BiZhiguo ZhangQingfeng LiuGuisheng Zhang; 关键词：SELECTFLUOR PEG-400 绿色化学

氨基硼烷化合物的合成及应用研究进展被引量：1: 2012年; 氨基硼烷化合物近年来在储氢材料的开发以及在有机合成中的应用非常广泛。本文综述了氨基硼烷的合成及其作为储氢材料的研究进展,以及近十几年来氨基硼烷在有机合成中作为还原试剂、在不对称还原反应中作手性催化剂及其他反应中的应用研究进展。指出加入金属氢化物制备的金属氨硼烷具有较优的放氢性能、可再生氨硼烷储氢材料的开发和制备是储氢材料新的发展方向;发展清洁高效的绿色还原体系和高选择性的手性氨硼烷催化剂是氨硼烷研究领域的新热点;氨硼烷试剂在储氢材料开发和绿色还原试剂领域具有潜在的实际应用价值。; 时蕾刘迎迎毛润泽张贵生; 关键词：储氢材料手性催化剂

Oxidative Nuclear Bromination of Substituted 4-Pyridones Using Pyridinium Bromochromate: Oxidative nuclear halogenation(ONH), essentially subordinate to the electrophilic halogenation[1], is an effec...; Qian,JingjingZhang,ZhiguoTian,QingLiu,TongxinLiu,Qingfeng; 关键词：PYRIDINIUM OXIDATIVE NUCLEAR BROMINATION OXIDATIVE BROMINATION

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长江学者和创新团队发展计划(IRT1061)