Abstract. Let {L(Ln^(A,λ)(x)}n≥0 be the sequence of monic Laguerre matrix polynomials defined on [0,∞) byLn^(A,λ)(x)=n!/(-λ)^n ∑nk-0(-λ)^k/k!(n-k)!(A+I)n[(A+I)k]^-1x^k,where A ∈ C^r×r. It is known that {Ln^(A,λ)(x)}n≥0 is orthogonal with respect to a matrix moment functional when A satisfies the spectral condition that Re(z) 〉 -1 for every z E or(a). In this note we show that forA such that σ(A) does not contain negative integers, the Laguerre matrix polynomials Ln^(A,λ)(x) are orthogonal with respect to a non-diagonal SobolevLaguerre matrix moment functional, which extends two cases: the above matrix case and the known scalar case.