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国家自然科学基金(11072094)

作品数:12 被引量:18H指数:3
相关作者:周又和王记增刘小靖王晓敏更多>>
相关机构:兰州大学更多>>
发文基金:国家自然科学基金教育部“新世纪优秀人才支持计划”国家教育部博士点基金更多>>
相关领域:理学生物学医药卫生航空宇航科学技术更多>>

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12 条 记 录,以下是 1-10
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微管反常力学性能研究
<正>微管作为构成细胞骨架的三类基本纤维之一,在真核细胞的许多生理活动中充当着关键角色,尤其是微管的力学性能往往决定着细胞能否准确执行其相关生理功能。典型的微管是由13根纤维原丝平行组装而成的细长空心圆管。由于纤维原丝内...
刘小靖王记增周又和
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DNA从噬菌体内喷出的统计热动力学模型
<正>研究DNA从噬菌体内喷出的分子生物力学过程与机理,对理解病毒侵染细胞的基础生物学过程,和设计具有靶向定点能力与释放率可控的纳米药物输送载体等有着重要意义。大量实验表明,噬菌体先是将尾鞘插入细胞壁,利用相关蛋白质分子...
李珑王记增
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Stretching strongly confined semiflexible polymer chain被引量:1
2014年
By the so-called wormlike chain (WLC) model in polymer physics envision- ing an isotropic rod that is continuously flexible, the force-extension relations of semi- flexible polymer chains strongly constrained by various confinements are theoretically investigated, including a slab-like confinement where the polymer chains are sandwiched between two parallel impenetrable walls, and a capped nanochannel confinement with a circular or rectangular cross-section where the chains are bounded in three directions. The Brownian dynamics (BD) simulations based on the generalized bead-rod (GBR) model are performed to verify the theoretical predictions.
王记增李润华
关键词:CONFINEMENT
Fractional stochastic description of hinge motions in single protein molecules被引量:1
2011年
In this study, it is demonstrated that the motion of hinges in single protein molecules can be modeled as general fractional Langevin dynamics of harmonically bound particles driven by non-local Gaussian noise with a power-law correlation. This conclusion was justified by comparing the theoretical predictions of the proposed model to the existing molecular dynamics simulations performed on the M6I mutant of phage T4 lysozyme and E. coli ribonuclease H1.
WANG JiZeng
关键词:分子运动核糖核酸酶
Specific adhesion of a soft elastic body on a wavy surface
2012年
This paper aims at developing a stochastic-elastic model of a soft elastic body adhering on a wavy surface via a patch of molecular bonds. The elastic deformation of the system is modeled by using continuum contact mechanics, while the stochastic behavior of adhesive bonds is modeled by using Bell's type of exponential bond association/dissociation rates. It is found that for sufficiently small adhesion patch size or stress concentration index, the adhesion strength is insensitive to the wavelength but decreases with the amplitude of surface undulation, and that for large adhesion patch size or stress concentration index, there exist optimal values of the surface wavelength and amplitude for maximum adhesion strength.
Jizeng WangJinyan YaoHuajian Gao
关键词:ROUGHNESS
Mechanics of DNA packaging and ejection from elastic phage capsid
2013年
This study intends to investigate how the elasticity of a bacterial phage can affect the process of DNA packaging and ejection. For this purpose, we propose a unified continuum and statistical mechanics model by taking into account the effects of DNA bending deformation, electrostatic repulsion between DNA-DNA strands and elastic deformation of the phage capsid. Based on such a model, we derive the quantitative relations between packaging force, elasticity of capsid, DNA length remaining in the capsid, osmotic pressure and ejection time. The theoretically predicted results are found to agree very well with in vitro experimental observations in the lit-erature.
Long LiJizeng WangYouhe Zhou
关键词:EJECTIONPHAGE
一种适用于强非线性结构力学问题数值求解的修正小波伽辽金方法被引量:7
2011年
论文通过对有限区间上的任一连续函数在边界处采用基于泰勒展开的延拓处理,构造了一种与任意边界条件相协调的改进小波尺度基函数及在此基础上建立了小波逼近格式,由此可有效避免小波逼近在求解微分方程时在边界处的跳跃或抖动问题.在此基础上,结合论文后两位作者提出的广义小波高斯积分法,关于未知函数的任意非线性项的小波展开可以显式地用原未知函数的展开系数表征,据此建立了一种可适用于求解任意强非线性的梁弯曲问题的小波伽辽金方法.该方法具有解的封闭性与计算简单等特点.通过定量求解包含幂次非线性与非幂次非线性项梁的两例大挠度弯曲问题,所得结果表明论文所建立的方法具有良好的数值精度.
刘小靖王记增周又和
关键词:强非线性弹性梁
微型支抗种植体结构设计的非线性有限元分析
在正畸治疗过程中,正确地进行支抗控制是影响矫治效果的关键因素。传统支抗因其异物感强、美观度差、结构复杂等缺点,在临床上不容易获得理想的治疗效果。然而,由于体积小、结构简单、配合度高等优点,微型支抗种植体很好的克服了上述缺...
陈宏伟安晓莉周又和王记增
圆管约束下聚合物链力与变形关系布朗动力学仿真研究
半柔性聚合物分子在复杂受力与空间约束下具有怎样的统计热力学性质,一直是近半个世纪以来软物质科学领域中既基础又非常有挑战性的课题。在这一领域,人们比较认可的两项工作是de Genne教授和Odijk教授分别提出的在中等强度...
李润华王记增
Creep effect on cellular uptake of viral particles被引量:3
2014年
Receptor diffusion on cell membrane is usually believed as a major factor that controls how fast a virus can enter into host cell via endocytosis.However,when receptors are densely distributed around the binding site so that receptor recruiting through diffusion is no longer energetically favorable,we thus hypothesize that another effect,the creep deformation of cytoskeleton,might turn to play the dominant role in relaxing the engulfing process.In order to deeply understand this mechanism,we propose a viscoelastic model to investigate the dynamic process of virus engulfment retarded by the creep deformation of cytoskeleton and driven by the binding of ligand-receptor bonds after overcoming resistance from elastic deformation of lipid membrane and cytoskeleton.Based on this new model,we predict the lower bound of the ligand density and the range of virus size that allows the complete engulfment,and an optimal virus size corresponding to the smallest wrapping time.Surprisingly,these predictions can be reduced to the previous predictions based on simplified membrane models by taking into account statistical thermodynamic effects.The results presented in this study may be of interest to toxicologists,nanotechnologists,and virologists.
Jizeng WangLong LiYouhe Zhou
关键词:病毒颗粒蠕变效应细胞膜受体粘弹性模型蠕变变形
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