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国家重点基础研究发展计划(2013CB933000)

作品数:10 被引量:73H指数:4
相关作者:江雷刘明杰王鹏伟张靓赵宁更多>>
相关机构:中国科学院北京航空航天大学中国科学院大学更多>>
发文基金:国家重点基础研究发展计划国家自然科学基金中国科学院重点部署项目更多>>
相关领域:理学一般工业技术自动化与计算机技术生物学更多>>

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10 条 记 录,以下是 1-10
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新型仿生微纳米界面微量流体输运调控材料
2015年
生物表面从微纳米层次上已提供给人类一种多级次梯度结构的协同效应机制,并展现出控制动态浸润性及液体传输的独特能力。基于这种机制,设计了各种仿生的结构,开发了制备仿生材料的新技术与方法。并将仿生理念引入到材料的制备中,通过利用常见的高分子材料、响应高分子材料、掺杂的有机物/无机物复合材料,可控制备了一系列新型一、二维度仿生微纳米界面材料。这些新型仿生微纳米界面材料从微、纳及宏观层次上体现了优越的浸润性调控功能,如液滴驱动、水收集、防覆冰等,其在微流控制、淡水采集、雾水工程、热量传递、浮尘过滤等领域有重要的应用前景。
张明乾周蕾杨守斌郑咏梅
关键词:微纳米结构浸润性憎水性
An AIEgens and exonuclease Ⅲ aided quadratic amplification assay for detecting and cellular imaging of telomerase activity被引量:5
2017年
Monitoring telomerase activity with high sensitive and reliable is of great importance to cancer analysis. In this paper, we report a sensitive and facile method to detect telomerase activity using AIEgens mod- ified probe (TPE-Py-DNA) as a fluorescence reporter and exonuclease llI (Exo lIl) as a signal amplifier. With the aid of telomerase, repeat units (TrAGGG)n are extended from the end of template substrate oligonucleotides (TS primer) that form duplex DNAs with TPE-Py-DNA. Then, Exo llI catalyzes the diges- tion of duplex DNAs, liberating elongation product and releasing hydrophobic TPE-Py. The released hydrophobic TPE-Py aggregate together and produce a telomerase-activity-related fluorescence signal. The liberated product hybridizes with another TPE-Py-DNA probe, starting the second cycle. Finally, we obtain the target-to-signal amplification ratio of 1 :N2. This strategy exhibits good performance for detecting clinical urine samples (distinguishing 15 cancer patients' samples from 8 healthy ones) and checking intracellular telomerase activity (differentiating cell lines including HeLa, MDA-MB-231, MCF-7, A375, HLF and MRC-5 from the cells pretreated with telomerase-related drug), which shows its potential in clinical diagnosis as well as therapeutic monitoring of cancer.
Xuehong MinLei XiaYuan ZhuangXudong WangJie DuXiaojin ZhangXiaoding LouFan Xia
溶剂蒸汽退火法制备有机小分子半导体单晶被引量:4
2015年
溶剂蒸汽退火(Solvent Vapor Annealing,SVA)是一种经济高效的小分子半导体晶体生长制备方法.本工作通过该方法制备出了多种小分子有机半导体单晶,通过偏光显微镜,XRD,TEM和AFM对得到的单晶的形貌和晶体结构进行了表征.此外,我们对退火所用溶剂的溶解度、蒸汽退火的环境温度和聚合物介质的引入等影响因素进行了讨论.研究发现,SVA过程中随着退火溶剂对有机半导体的溶解度增大,得到的晶体尺寸也随之增大;此外,当退火温度升高,晶体生长速度加快,但当温度接近溶剂蒸汽的沸点时,晶体极易产生缺陷;聚合物的引入可以大大促进SVA进程,并且生长得到的有机半导体单晶缺陷更少,尺寸更大.
吴君辉袁艺高明圆王哲江雷
关键词:有机半导体单晶
微孔PI气体分离膜的研究进展被引量:7
2016年
自具微孔材料(PIMs)由于自身刚性分子链的扭曲折叠等会产生高比表面积的微孔结构,相应的膜材料具有优异的气体分离性能。将刚性扭曲的结构单元引入到聚酰亚胺(PI)主链中就得到自具微孔PI。微孔型PI是近年来发展的一种新型PI,其微孔结构使得PI膜的气体分离性能得到很大提升,其中气体渗透系数的提升尤为显著,且保持了传统PI良好的热稳定性、化学稳定性及高力学强度等性质。本文重点介绍了微孔PI以及基于微孔PI复合膜的最新研究进展,并对其未来发展趋势进行了展望。
任会婷王正宫张丰靳健
关键词:气体分离膜
仿生多尺度超浸润界面材料被引量:31
2016年
仿生多尺度超浸润界面材料是20世纪90年代末以来迅速发展起来的一类新型功能材料,该研究领域突出的特点是基础研究和应用研究密切结合、仿生理念与材料制备技术密切结合.近年来,研究人员围绕仿生多尺度超浸润界面材料的构筑与应用中的若干关键科学问题开展了深入研究,取得了一系列有特色、有创新意义的研究成果,开发出了一系列的材料制备新方法和新技术.本文首先介绍仿生多尺度超浸润界面材料的发展历程和固体表面浸润性的理论基础;然后讨论对自然界中具有特殊浸润性能的功能表面的原理揭示和仿生设计;对仿生多尺度超浸润界面材料的典型应用领域,例如自清洁、集水、防冰、油水分离以及化学反应等进行了总结;最后对仿生多尺度超浸润界面材料的发展前景进行了讨论.
王鹏伟刘明杰江雷
关键词:仿生
特殊浸润性表面在油水分离中的应用被引量:17
2013年
表面浸润性是固体表面的重要性质之一.近年来,包括超疏水表面、超亲水表面和超亲油表面在内的特殊浸润性表面在日常生活和工业生产中具有的广阔的应用前景,引起了研究者的广泛关注,其中特殊浸润性表面在油水分离中的应用是研究热点之一.油水分离技术在化学化工领域有着重要影响,例如原油泄漏的回收和有机试剂的分离等.由于一般情况下油和水表面张力不同,可以选择对油和水亲和力不同的表面对其进行分离,通过使表面具备特殊浸润性,从而增强油水分离效率.本文从(1)超疏水超亲油表面,(2)水下超亲油表面和(3)可逆转变表面3部分总结了特殊浸润性表面用于油水分离的研究进展,并对本领域目前的研究难点和未来的研究方向进行总结和展望.
张靓赵宁徐坚
关键词:浸润性油水分离超疏水超亲水
Orientated-assembly of rod-like silica particles based on sandwich structure from the superhydrophobic template and the superhydrophilic substrates
2016年
The paper demonstrated a facile approach for the orientated assembly of the rod-like silica particles by sandwich structure from the combined effect of superhydrophobic template and the superhydrophilic substrates. The rod-like particles can be arranged in ring-like, square-like and etc from the confined effect of the template, which will produce an important insight for the oriented assembly ofanisotropic particles and the development of the novel functional materials and devices.
Lun WanChen-Hui JiaoMan-Bo ZhangJing-Xia WangLei Jiang
关键词:SELF-ASSEMBLY
DNA hybridization chain reaction and DNA supersandwich self-assembly for ultrasensitive detection被引量:4
2017年
The fabrication of sensitive sensors with high selectivity is highly desirable for the detection of some important biomarkers,such as nucleic acids,proteins,small molecules and ions.DNA hybridization chain reaction(HCR) and DNA supersandwich self-assembly(SSA) are two prevalent enzyme-free signal amplification strategies to improve sensitivity of the sensors.In this review,we firstly describe the characteristics about DNA HCR and DNA SSA,and then summarize the advances in the one-dimensional DNA nanostructures assisted by HCR and SSA.This review has been divided into three parts according to the two signal amplification methods and highlights recent progress in these two strategies to improve the detection sensitivity of proteins,nucleic acids,small molecules and ions.
Nannan LiuFujian HuangXiaoding LouFan Xia
A highly sensitive DNA-AIEgen-based "turn-on" fluorescence chemosensor for amplification analysis of Hg^2+ ions in real samples and living cells被引量:4
2017年
Functional nucleic acids(FNAs)-based biosensors have shown great potential in heavy metal ions detection due to their low-cost and easy to operate merits. However, in most FNAs based fluorescence probes, the ingenious designs of double-labeled(fluorophore and quencher group) DNA sequence, not only bring the annoyance of organic synthesis, but also restrict its use as a robust biosensor in practical duties. In this paper, we design a simple AIEgens functional nucleic acids(AFNAs) probe which consists of only fluorogen but no quencher group. With the help of duplex-specific nuclease(DSN) enzyme based target recycling, high fluorescence signal and superior sensitivity towards Hg^(2+) are achieved. This robust assay allows for sensitive and selective detection of Hg^(2+) in real water samples and mapping of intracellular Hg^(2+), without double-labeling of oligonucleotide with a dye-quencher pair, nor the multiple assay steps.
Xiaowen OUXiaoding LouFan Xia
Recent advances in optical-based and force-based single nucleic acid imaging被引量:2
2017年
The capability to image, as well as control and manipulate single molecules such as nucleic acids(DNA or RNA) can greatly enrich our knowledge of the roles of individual biomolecules in cellular processes and their behavior in native environments. Here we summarize the recent advances of single nucleic acid imaging based on optical observation and force manipulation. We start by discussing the superiority of single molecule image, the central roles nucleic acids play in biosystems, and the significance of single molecule image towards nucleic acids. We then list a series of representative examples in brief to illustrate how nucleic acid of various morphologies has been imaged from different aspects, and what can be learned from such characterizations. Finally,concluding remarks on parts of which should be improved and outlook are outlined.
Shenshan ZhanXiaoding LouFan Xia
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