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国家自然科学基金(81001249)

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男性儿童青少年血清Apelin遗传度及影响因素双生子研究被引量:1
2014年
目的利用双生子研究分析影响男性儿童青少年血清Apelin的遗传和环境因素,为探讨年龄、体质量指数(BMI)和肥胖在其中的作用提供依据。方法选择7~18岁男性双生子162名,平均年龄(12.2±3.7)岁,其中同卵双生子100名,异卵双生子62名。利用DNA微卫星多态性鉴定卵性。应用Mx结构方程模型分别计算年龄、BMI及肥胖调整前后Apelin的遗传度,并分析年龄、BMI和肥胖对Apelin的影响。结果 Apelin水平与年龄呈正相关,肥胖组男童Apelin水平低于正常组(P〈0.05)。Apelin的遗传度为41%,共同环境方差和独特环境方差分别占37%和22%。调整年龄、BMI及肥胖后,遗传方差比例降低。结论男性儿童青少年Apelin水平与年龄、肥胖度相关。Apelin受遗传和环境因素的共同影响。
陈天娇季成叶李晓娟王莹李劲
关键词:青少年双生子研究环境暴露
Secular Changes of Stature in Rural Children and Adolescents in China, 1985-2010被引量:8
2014年
Objective To analyze and assess secular change in stature in rural children and adolescents in China from 1985 to 2010. Methods Data were obtained from the 6 rounds of the Chinese National Survey on Student's Constitution and Health. The subjects enrolled in the study were children and adolescents aged 7-18 years in rural areas of provincial capitals. Results An overall positive secular trend in stature occurred in rural areas of provincial capitals in China from 1985 to 2010. The overall average increase rates were 3.1 and 2.4 cm/decade for boys and girls, respectively. The total body height increases for grown up boys and girls were 3.6 and 2.3 cm and the increase rates were 1.4 and 0.9 cm/decade, respectively. There were differences in body height increase among eastern, central and western regions. The average body height of the children or adolescents in eastern region was highest, followed by central region and western region. The overall increase rates in central region were highest among the three regions. The difference between eastern/central region and western region was obvious. 〈br〉 Conclusion Positive secular trend in stature of children or adolescents has occurred in rural area of China, and rural boys and girls showed a great potential for continuous growth. More attention should be paid to the differences in children's body height between western region and eastern/central region.
CHEN Tian JiaoJI Cheng Ye
关键词:STATURE
Secular Change in Stature of Urban Chinese Children and Adolescents, 1985-2010被引量:8
2013年
Objective Research evidence shows a secular trend in Chinese physical growth in recent years.The aim of this study was to analyze and assess changes in stature of children and adolescents during the 25 years from 1985‐2010,using national data.Methods Data came from successive cycles of the Chinese National Survey on Students' Constitution and Health(CNSSCH).Subjects were 7‐ to 18‐year‐old children and adolescents.Results An overall positive secular trend occurred in urban China during 1985‐2010.The overall average rates of increment were 2.4 and 1.7 cm/decade for boys and girls,respectively.Total increases in adult stature for boys and girls were 2.6 and 1.7 cm,yielding rates of 1.0 and 0.7 cm/decade,respectively.Cities with different socioeconomic levels had different characteristic trends.Mean stature increases in big cities were larger than those in moderate and small cities,and boys and girls in moderate and small cities showed greater potential for growth in stature.Conclusion An overall positive secular growth trend was associated with socioeconomic progress and differed with area socioeconomic levels.School policies and strategies should be developed based on increased stature,and should continue narrowing the inequity between different socioeconomic populations.
CHEN Tian JiaoJI Cheng Ye
关键词:STATUREGROWTH
双生子瘦素的遗传度估计及影响因素分析
脂肪组织内分泌功能的发现是近几年内分泌学科领域的重要进展之一。研究表明,脂肪组织不仅是能量储存器官,而且是控制能量平衡的内分泌器官,与脂肪代谢、能量平衡、胰岛素敏感性和内环境稳定等有关。脂肪组织分泌多种具有生理活性的蛋白...
陈天娇季成叶王莹
关键词:BMI瘦素水平
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中国纳西族儿童青少年营养促进实施状况及其建议被引量:9
2014年
目的分析25年来纳西族儿童青少年营养状况改善情况,并提出持续改善措施的建议。方法2010年调查云南省丽江市纳西族7~18岁儿童青少年2635人,以当地汉族乡村同龄人群作为对照,采用WHO-2006标准筛查营养不良。结果2635名纳西族儿童青少年男女生长迟缓率分别为4.9%和4.7%,消瘦率分别为5.6%和4.6%,合计营养不良率分别为10.5%和9.3%,比对照组分别下降35.2%和44.1%。结论纳西族儿童青少年营养状况显著改善导致旺盛的生长长期趋势。建议针对存在的问题促进膳食多元化,提高疾病防治水平,并改善和加强基层妇幼保健、优生优育等措施。
季成叶
关键词:营养不良生长发育纳西族儿童青少年
儿童青少年注意问题和焦虑/抑郁相关遗传与环境因素影响的双生子研究被引量:3
2017年
目的探讨遗传和环境因素对儿童青少年注意问题和焦虑/抑郁关联的影响。方法对1062名同性别6~18岁双生子,采用Achenbach儿童行为量表家长用问卷进行调查。使用Mx软件拟合结构方程的单变量模型。构建Cholesky分解模型分析注意问题和焦虑/抑郁中的遗传和环境影响相关。结果注意问题与焦虑/抑郁有遗传相关(r=0.48),共享环境因素相关作用为0.86,非共享环境因素相关作用为0.14。结论遗传因素和共享环境因素对注意问题和焦虑/抑郁的相关起重要作用,非共享环境因素对相关所起作用较小。
王上上陈天娇季成叶
关键词:双生子儿童青少年
Secular Changes on the Distribution of Body Mass Index among Chinese Children and Adolescents, 1985-2010被引量:9
2013年
Objective To analyze the change in Body Mass Index (BMI) distribution among Chinese children and adolescents for the development of more effective intervention for childhood obesity. Methods Data on the national students' constitution and health survey between 1985 and 2010 was used for this study. Subjects were students aged 7-18 randomly selected from 30 provinces in China. BMI for-age curves were developed by LMS method, and the trend of BMI distribution was determined by comparing the upper BMI percentiles and analyzing the skew shift of distribution between 2985 and 2010. Results An overall positive swift trend of BMI between 1985 and 2010 was observed among the Chinese school-age children and adolescents. The average median of the BMI increased from 16.8 and 17.0 ks/m2 to 18.2 and 17.9 kg/m2 in 25 years, with increments 0.56 and 0.36 kg/m2 per decade for males and females, respectively. The more obvious increments were found at the high BMI. The total increments of BMI in this period were 4.03 and 2.20 kg/m2 at the 85th, 6.24 and 3.57 kg/m2 at the 95th, and 6.99 and 4.27 kg/m2 at the 97th percentiles, for males and females, respectively. Conclusion Obvious increments were observed at high BMI of the Chinese children and adolescents. More effective interventions should be taken for control and prevention of obesity and its health consequence for these subgroups. It is necessary to establish a risk-complex system consisting of the identification of BMI scope, the screen of the disease risk factors and the assessment of excessive adiposity.
JI Cheng YeCHEN Tian JiaoSUN Xiao
关键词:OBESITY
父亲教养方式对儿童双生子行为问题的效应及性别差异被引量:8
2017年
目的了解父亲教养方式对儿童行为问题的效应,为进一步探寻父亲教养方式与儿童行为问题间的因果关系提供线索。方法应用双生子研究分析法,收集2002—2013年北京地区和山东地区招募的186名同性别6~12岁双生子作为研究对象,每位被试完成父母教养方式评价量表(EMBU),由父母完成Achenbach儿童行为量表(CBCL)家长问卷。结果父亲拒绝否认(β=0.148,95%CI=0.011~0.327)会增加男生内化行为问题风险;父亲过分干涉(β=0.185,95%CI=0.023~0.400)、父亲拒绝否认(β=0.173,95%CI=0.035~0.390)、父亲过度保护(β=0.214,95%CI=0.075~0.623)会增加女生内化行为问题风险;父亲惩罚严厉会增加男生(β=0.126,95%CI=0.035~0.371)和女生(β=0.135,95%CI=0.007~0.234)双生子外化行为问题的风险。结论父亲教养方式与儿童行为问题存在效应关系。应重视父亲教养方式的影响,预防和减少儿童行为问题的发生。
杨阳陈天娇宋洁云季成叶
关键词:父亲双生子研究儿童
6~18岁双生子BMI遗传度及与青春期关系
2023年
目的分析山东省6~18岁双生子BMI的遗传度及青春期影响。方法于2021年11月通过山东省3县区453对6~18岁同性别双生子构建结构方程模型计算BMI遗传度,探究青春期对BMI遗传度的影响及性别差异。结果调整性别、年龄后6~18岁儿童青少年BMI的遗传度为0.84(95%CI=0.80~0.88),青春期前期BMI的遗传度为0.81(95%CI=0.74~0.86),青春期后期BMI的遗传度为0.88(95%CI=0.81~0.93);男生和女生青春期前期BMI遗传度分别为0.77(95%CI=0.67~0.85)和0.85(95%CI=0.77~0.91),青春期后期分别为0.92(95%CI=0.82~0.97)和0.86(95%CI=0.76~0.92)。结论遗传因素对青春期前后BMI变异具有重要影响,BMI的遗传度在青春期后期增加,且在男生中更为明显。
郭婷婷白云洁樊爱平范丽丽李元成陈天娇
关键词:体质指数双生子研究遗传度青春期
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