Based on the statistical results of the relationship between the large earthquakes surrounding Xinjiang and moderate earthquakes within Xinjiang since 1950,this article calculates the Coulomb failure stress change produced by the three groups of large earthquakes surrounding Xinjiang during the large earthquake active period outside Xinjiang and the quiet period inside Xinjiang from 1976 to 2007,and analyzes Xinjiang's moderate earthquake activity features in the three years after the large earthquakes surrounding Xinjiang. It then discusses the influence of large earthquake activity surrounding Xinjiang on seismic activity within Xinjiang. The research results show that the large earthquake activity surrounding Xinjiang may to a certain extent slow down the preparation process of moderate earthquakes in Xinjiang.