A theory of a class of higher order singular integral under the operator(Lf)(u)=1/(ū [ū1 f u 1(u) 1 f ū1(u)+f(u)] is given.We transform the higher order singular integral to a usual Cauchy integral,extend the permutation formula of the higher order singular integral deduced by Qian and Zhong in [4] to a general case,and discuss the regularization problem of the higher order singular integral equations with Cauchy kernel and variable coefficients on complex hypersphere.