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中国博士后科学基金(2012M510459)

作品数:2 被引量:17H指数:2
相关作者:张寅平屈芳更多>>
相关机构:清华大学更多>>
发文基金:中国博士后科学基金国家自然科学基金国家科技支撑计划更多>>
相关领域:医药卫生更多>>

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Increasing prevalence of asthma and allergy in Beijing pre-school children: Is exclusive breastfeeding for more than 6 months protective?被引量:3
2013年
This study evaluated the prevalence and risk factors for asthma,allergy and related symptoms;and breastfeeding patterns and durations for 5479 Beijing children aged 3–6.Parents of children in randomly selected kindergartens wrote responses to a questionnaire used previously.The study aimed to evaluate trends in the prevalence of asthma and related illnesses,and to determine whether"more"breastfeeding,defined as exclusive,>6 months,was associated with reduced prevalence.Asthma has increased in this age group between 1990 and 2011,with the steepest increase in the last 2–3 years.Of the total,14.2%(779)children were breastfed exclusively for>6 months.The efficacy of"more"breastfeeding was tested in a subset with two strong risk factors,positive family history(for asthma and/or allergy)and male gender."More"breastfeeding was found to be significantly protective(aOR 0.42,P<0.05)for this subset against Doctor-diagnosed asthma(D-asthma).Protection that did not reach statistical significance was also found for this subset against Wheeze ever,Cough at night,Rhinitis ever,Doctor-diagnosed rhinitis(D-rhinitis)and Eczema.The greatest protective effects were found for girls with no family history of asthma or allergy,reaching statistical significance for Wheeze ever(aOR 0.48,P<0.01),Cough at night(aOR 0.47,P<0.01),D-asthma(aOR 0.14,P<0.01)and Rhinitis ever(aOR 0.67,P<0.05)."More"breastfeeding was not consistently associated with either a protective or risk effect for Eczema.
QU FangWESCHLER Louise B.SUNDELL JanZHANG YinPing
纯母乳喂养对北京学龄前儿童哮喘和过敏性疾病患病率的影响被引量:14
2013年
调查了北京5479名3-6岁学龄前儿童哮喘(Doctor—diagnosedasthma,简称D—asthma)和过敏性疾病的患病率及主要危险因素,并讨论了母乳喂养方式和持续时间对患病率的影响.随机抽取北京各区幼儿园,被调查儿童的家长完成了本次问卷作答.该研究旨在评估儿童哮喘和过敏性疾病患病率的趋势,深入探讨纯母乳喂养6个月以上对患病率的影响.1990—2011年,北京儿童哮喘的患病率呈上升趋势,最近2~3年增幅最大.本次问卷调查显示,5479名北京儿童中纯母乳喂养6个月以上的有779例,占14.2%.以有家庭过敏史的男孩为例,纯母乳喂养6个月以上对其哮喘具有显著的保护作用(aOR0.42,P〈0.05);但对其哮鸣、干咳、鼻炎、确诊鼻炎及湿疹的保护作用均未达到统计学意义上的显著性水平.以无哮喘和过敏性疾病家庭过敏史的女孩为例,纯母乳喂养6个月以上对其健康效应呈现统计学意义上显著的保护作用:哮鸣(aOR0.48,P〈0.01)、干咳(a0R0.47,P〈0.01)、哮喘(aOR0.14,P〈0.01)和鼻炎(aOR0.67,P〈0.05).而纯母乳喂养6个月以上对儿童湿疹则未显示出统计学意义上的保护或危害作用.
屈芳WESCHLER Louise B.SUNDELL Jan张寅平
关键词:表观遗传鼻炎
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