In the constrained reentry trajectory design of hypersonic vehicles, multiple objectives with priorities bring about more difficulties to find the optimal solution. Therefore, a multi-objective reentry trajectory optimization (MORTO) approach via generalized varying domain (GVD) is proposed. Using the direct collocation approach, the trajectory optimization problem involving multiple objectives is discretized into a nonlinear multi-objective programming with priorities. In terms of fuzzy sets, the objectives are fuzzified into three types of fuzzy goals, and their constant tolerances are substituted by the varying domains. According to the principle that the objective with higher priority has higher satisfactory degree, the priority requirement is modeled as the order constraints of the varying domains. The corresponding two-side, single-side, and hybrid-side varying domain models are formulated for three fuzzy relations respectively. By regulating the parameter, the optimal reentry trajectory satisfying priorities can be achieved. Moreover, the performance about the parameter is analyzed, and the algorithm to find its specific value for maximum priority difference is proposed. The simulations demonstrate the effectiveness of the proposed method for hypersonic vehicles, and the comparisons with the traditional methods and sensitivity analysis are presented.